Human FVIII HLA-DRB1*1501–restricted T-cell–binding epitopes
| Epitope sequence . | At position . |
|---|---|
| TQTLHKFILLFAVFD | 208-222 |
| MHTVNGYVNRSLPGL | 250-264 |
| LGQFLLFCHISSHQH | 322-336 |
| DTLLIIFKNQASRPY | 478-492 |
| PRCLTRYYSSFVNME | 545-559 |
| TENIQRFLPNPAGVQ | 607-621 |
| DNIMVTFRNQASRPY | 1788-1802 |
| SLYISQFIIMYSLDG | 2114-2128 |
| GTLMVFFGNVDSSGI | 2140-2154 |
| PPIIARYIRLHPTHY | 2161-2175 |
| PPLLTRYLRIHPQSW | 2318-2332 |
| RYLRIHPQSWVHQIA | 2322-2336 |
| Epitope sequence . | At position . |
|---|---|
| TQTLHKFILLFAVFD | 208-222 |
| MHTVNGYVNRSLPGL | 250-264 |
| LGQFLLFCHISSHQH | 322-336 |
| DTLLIIFKNQASRPY | 478-492 |
| PRCLTRYYSSFVNME | 545-559 |
| TENIQRFLPNPAGVQ | 607-621 |
| DNIMVTFRNQASRPY | 1788-1802 |
| SLYISQFIIMYSLDG | 2114-2128 |
| GTLMVFFGNVDSSGI | 2140-2154 |
| PPIIARYIRLHPTHY | 2161-2175 |
| PPLLTRYLRIHPQSW | 2318-2332 |
| RYLRIHPQSWVHQIA | 2322-2336 |
Fifteen-mer high-affinity binding MHCII epitopes of the hFVIII protein were predicted for human HLA-DRB1*1501 alleles using bioinformatics tools. Peptides with amino acids highlighted in bold are designated by the first 5 N-terminal amino acids in their sequence.