Multivariable analysis for PFS and OS
| . | . | PFS . | OS . | Reference . | ||
|---|---|---|---|---|---|---|
| Variable . | . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| LDH at transplant | High LDH | 1.559 (0.887-2.739) | .1229 | 1.305 (0.725-2.348) | .3745 | Normal LDH |
| CNS involvement site | Leptomeningeal | 1.659 (0.781-3.522) | .1878 | 1.789 (0.801-3.998) | .156 | Parenchymal |
| Leptomeningeal and Parenchymal | 1.702 (0.653-4.433) | .2762 | 1.488 (0.553-4.003) | .4312 | ||
| CSF Only | 2.143 (0.67-6.849) | .1986 | 2.676 (0.806-8.882) | .1078 | ||
| Others* | 1.019 (0.396-2.622) | .9697 | 0.939 (0.331-2.667) | .9064 | ||
| Prior lines of therapy | ≤2 | 0.483 (0.266-0.876) | .0165 | 0.475 (0.252 - 0.896) | .0214 | Prior lines of therapy >2 |
| Time from diagnosis to transplant | ≤18 mo | 0.643 (0.354-1.167) | .1462 | >18 mo | ||
| Disease status at transplant | CR/ Cru | 0.268 (0.142-0.506) | <.0001 | 0.344 (0.175-0.677) | .002 | Not in remission |
| . | . | PFS . | OS . | Reference . | ||
|---|---|---|---|---|---|---|
| Variable . | . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| LDH at transplant | High LDH | 1.559 (0.887-2.739) | .1229 | 1.305 (0.725-2.348) | .3745 | Normal LDH |
| CNS involvement site | Leptomeningeal | 1.659 (0.781-3.522) | .1878 | 1.789 (0.801-3.998) | .156 | Parenchymal |
| Leptomeningeal and Parenchymal | 1.702 (0.653-4.433) | .2762 | 1.488 (0.553-4.003) | .4312 | ||
| CSF Only | 2.143 (0.67-6.849) | .1986 | 2.676 (0.806-8.882) | .1078 | ||
| Others* | 1.019 (0.396-2.622) | .9697 | 0.939 (0.331-2.667) | .9064 | ||
| Prior lines of therapy | ≤2 | 0.483 (0.266-0.876) | .0165 | 0.475 (0.252 - 0.896) | .0214 | Prior lines of therapy >2 |
| Time from diagnosis to transplant | ≤18 mo | 0.643 (0.354-1.167) | .1462 | >18 mo | ||
| Disease status at transplant | CR/ Cru | 0.268 (0.142-0.506) | <.0001 | 0.344 (0.175-0.677) | .002 | Not in remission |
CRu, complete response uncertain; CSF, cerebospinal fluid.
Included patients with isolated neurolymphomatosis, intramedullary spinal dissemination, and others not otherwise classified such as epidural with nerve root or spine involvement.