Multivariate Cox analysis: predictive effect of Day100 score on cGVHD, TRM, and survival in the validation set
| . | cGVHD . | TRM . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Day100 score | |||||||||
| Int. vs low | 1.91 | 1.26-2.89 | .002 | 2.01 | 1.24-3.25 | .007 | 1.30 | 0.99-1.70 | .05 |
| High vs low | 2.31 | 1.21-4.42 | .01 | 2.45 | 1.29-4.67 | .002 | 1.55 | 1.02-2.36 | .03 |
| Karnofsky <90% | — | — | — | 2.29 | 1.60-3.27 | <.0001 | 1.86 | 1.45-2.04 | <.0001 |
| Diagnosis AL vs other | — | — | — | — | — | — | 1.71 | 1.34-2.19 | <.0001 |
| Year of transplant | |||||||||
| 2000-2009 vs <2000 | 0.75 | 0.50-1.12 | .07 | 0.41 | 0.26-0.65 | .002 | 0.79 | 0.59-1.06 | .11 |
| 2010-2016 vs <2000 | 0.69 | 0.38-1.24 | .06 | 0.41 | 0.24-0.69 | .007 | 0.57 | 0.40-0.80 | .001 |
| no CR vs CR | — | — | — | — | — | — | 2.22 | 1.70-2.90 | <.0001 |
| Donor sex F→M vs other | — | — | — | 1.60 | 1.09-2.33 | .008 | — | — | — |
| aGVHD II-IV | 2.09 | 1.46-2.98 | .001 | — | — | — | — | — | — |
| Cy post: yes vs no | — | — | — | — | — | — | — | — | — |
| ATG: yes vs no | 0.57 | 0.36-0.89 | .01 | — | — | — | — | — | — |
| Stem cell source | |||||||||
| PB vs BM | 2.06 | 135-3.20 | .0009 | — | — | — | — | — | — |
| CB vs BM | — | — | — | — | — | — | — | — | — |
| Recipient age (cont) | — | — | — | 1.03 | 1.02-1.05 | .0001 | 1.02 | 1.01-1.03 | <.0001 |
| Donor age (cont) | — | — | — | — | — | — | — | — | — |
| . | cGVHD . | TRM . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Day100 score | |||||||||
| Int. vs low | 1.91 | 1.26-2.89 | .002 | 2.01 | 1.24-3.25 | .007 | 1.30 | 0.99-1.70 | .05 |
| High vs low | 2.31 | 1.21-4.42 | .01 | 2.45 | 1.29-4.67 | .002 | 1.55 | 1.02-2.36 | .03 |
| Karnofsky <90% | — | — | — | 2.29 | 1.60-3.27 | <.0001 | 1.86 | 1.45-2.04 | <.0001 |
| Diagnosis AL vs other | — | — | — | — | — | — | 1.71 | 1.34-2.19 | <.0001 |
| Year of transplant | |||||||||
| 2000-2009 vs <2000 | 0.75 | 0.50-1.12 | .07 | 0.41 | 0.26-0.65 | .002 | 0.79 | 0.59-1.06 | .11 |
| 2010-2016 vs <2000 | 0.69 | 0.38-1.24 | .06 | 0.41 | 0.24-0.69 | .007 | 0.57 | 0.40-0.80 | .001 |
| no CR vs CR | — | — | — | — | — | — | 2.22 | 1.70-2.90 | <.0001 |
| Donor sex F→M vs other | — | — | — | 1.60 | 1.09-2.33 | .008 | — | — | — |
| aGVHD II-IV | 2.09 | 1.46-2.98 | .001 | — | — | — | — | — | — |
| Cy post: yes vs no | — | — | — | — | — | — | — | — | — |
| ATG: yes vs no | 0.57 | 0.36-0.89 | .01 | — | — | — | — | — | — |
| Stem cell source | |||||||||
| PB vs BM | 2.06 | 135-3.20 | .0009 | — | — | — | — | — | — |
| CB vs BM | — | — | — | — | — | — | — | — | — |
| Recipient age (cont) | — | — | — | 1.03 | 1.02-1.05 | .0001 | 1.02 | 1.01-1.03 | <.0001 |
| Donor age (cont) | — | — | — | — | — | — | — | — | — |
See Table 3 for term definitions.