Molecular characteristics of mutant TP53 AML/MDS-EB (n = 230)
| . | AML (n = 186) . | MDS-EB (n = 44) . | AML/MDS-EB (n = 230) . | P . |
|---|---|---|---|---|
| TP53 mutant allelic status, no. (%) | .241 | |||
| Mono-allelic | 42 (23) | 14 (32) | 56 (24) | |
| Bi-allelic | 144 (77) | 30 (68) | 174 (76) | |
| Number of TP53 mutations, no. (%) | .153 | |||
| Single | 150 (81) | 31 (70) | 181 (79) | |
| Multiple | 36 (19) | 13 (30) | 49 (21) | |
| Mutant TP53 clone size, VAF (%) | .409 | |||
| Median | 48 | 41 | 47 | |
| Range | 1-97 | 3-91 | 1-97 | |
| Mutation at diagnosis, no. (%) | ||||
| Any concurrent | 95 (51) | 18 (41) | 113 (49) | .244 |
| DNMT3A | 25 (13) | 6 (14) | 31 (13) | 1.000 |
| TET2 | 17 (9) | 3 (7) | 20 (9) | .773 |
| ASXL1 | 10 (5) | 2 (5) | 12 (5) | 1.000 |
| RUNX1 | 10 (5) | 1 (2) | 11 (5) | .695 |
| SRSF2 | 11 (6) | 1 (2) | 12 (5) | .471 |
| . | AML (n = 186) . | MDS-EB (n = 44) . | AML/MDS-EB (n = 230) . | P . |
|---|---|---|---|---|
| TP53 mutant allelic status, no. (%) | .241 | |||
| Mono-allelic | 42 (23) | 14 (32) | 56 (24) | |
| Bi-allelic | 144 (77) | 30 (68) | 174 (76) | |
| Number of TP53 mutations, no. (%) | .153 | |||
| Single | 150 (81) | 31 (70) | 181 (79) | |
| Multiple | 36 (19) | 13 (30) | 49 (21) | |
| Mutant TP53 clone size, VAF (%) | .409 | |||
| Median | 48 | 41 | 47 | |
| Range | 1-97 | 3-91 | 1-97 | |
| Mutation at diagnosis, no. (%) | ||||
| Any concurrent | 95 (51) | 18 (41) | 113 (49) | .244 |
| DNMT3A | 25 (13) | 6 (14) | 31 (13) | 1.000 |
| TET2 | 17 (9) | 3 (7) | 20 (9) | .773 |
| ASXL1 | 10 (5) | 2 (5) | 12 (5) | 1.000 |
| RUNX1 | 10 (5) | 1 (2) | 11 (5) | .695 |
| SRSF2 | 11 (6) | 1 (2) | 12 (5) | .471 |