Association of candidate HLA-DPB1-recipient variants with aGVHD and relapse after HCT
| . | . | . | . | . | . | Discovery results . | Replication results . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant . | Alleles* . | Cohort . | Endpoint . | Model . | MAF† . | P . | HR . | LB . | UB . | Signals . | Bf-C . | P . | HR . | LB . | UB . | Power‡ . |
| rs9277378 | A/G | ALL | GVHD2b | Dominant | 0.29 | .003 | 1.19 | 1.1 | 1.3 | 6 | 0.008 | .01 | 1.20 | 1.0 | 1.4 | 41 |
| rs9277378 | A/G | URD | GVHD2b | Allelic | 0.28 | .0008 | 1.28 | 1.1 | 1.5 | 9 | 0.006 | .008 | 1.28 | 1.1 | 1.5 | 47 |
| rs9277535 | A/G | URD | GVHD2b | Allelic | 0.24 | .003 | 1.26 | 1.1 | 1.5 | 9 | 0.006 | .01 | 1.27 | 1.1 | 1.5 | 39 |
| rs9277542 | T/C | URD | GVHD2b | Allelic | 0.29 | .0004 | 1.29 | 1.1 | 1.5 | 9 | 0.006 | .006 | 1.28 | 1.1 | 1.5 | 54 |
| rs9277378 | A/G | ALL | Relapse | Recessive | 0.29 | .002 | 0.63 | 0.5 | 0.9 | 1 | 0.05 | .05 | 0.72 | 0.5 | 1.0 | 73 |
| rs9277542 | T/C | ALL | Relapse | Recessive | 0.29 | .0004 | 0.59 | 0.4 | 0.8 | 1 | 0.05 | .04 | 0.70 | 0.5 | 1.0 | 83 |
| rs9277378 | A/G | URD | Relapse | Recessive | 0.29 | .001 | 0.40 | 0.2 | 0.8 | 1 | 0.05 | .03 | 0.49 | 0.2 | 1.0 | 71 |
| rs9277535 | A/G | URD | Relapse | Recessive | 0.24 | .005 | 0.40 | 0.2 | 0.9 | 1 | 0.05 | .02 | 0.41 | 0.2 | 1.0 | 53 |
| rs9277542 | T/C | URD | Relapse | Recessive | 0.29 | .0008 | 0.39 | 0.2 | 0.7 | 1 | 0.05 | .01 | 0.45 | 0.2 | 0.9 | 73 |
| . | . | . | . | . | . | Discovery results . | Replication results . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant . | Alleles* . | Cohort . | Endpoint . | Model . | MAF† . | P . | HR . | LB . | UB . | Signals . | Bf-C . | P . | HR . | LB . | UB . | Power‡ . |
| rs9277378 | A/G | ALL | GVHD2b | Dominant | 0.29 | .003 | 1.19 | 1.1 | 1.3 | 6 | 0.008 | .01 | 1.20 | 1.0 | 1.4 | 41 |
| rs9277378 | A/G | URD | GVHD2b | Allelic | 0.28 | .0008 | 1.28 | 1.1 | 1.5 | 9 | 0.006 | .008 | 1.28 | 1.1 | 1.5 | 47 |
| rs9277535 | A/G | URD | GVHD2b | Allelic | 0.24 | .003 | 1.26 | 1.1 | 1.5 | 9 | 0.006 | .01 | 1.27 | 1.1 | 1.5 | 39 |
| rs9277542 | T/C | URD | GVHD2b | Allelic | 0.29 | .0004 | 1.29 | 1.1 | 1.5 | 9 | 0.006 | .006 | 1.28 | 1.1 | 1.5 | 54 |
| rs9277378 | A/G | ALL | Relapse | Recessive | 0.29 | .002 | 0.63 | 0.5 | 0.9 | 1 | 0.05 | .05 | 0.72 | 0.5 | 1.0 | 73 |
| rs9277542 | T/C | ALL | Relapse | Recessive | 0.29 | .0004 | 0.59 | 0.4 | 0.8 | 1 | 0.05 | .04 | 0.70 | 0.5 | 1.0 | 83 |
| rs9277378 | A/G | URD | Relapse | Recessive | 0.29 | .001 | 0.40 | 0.2 | 0.8 | 1 | 0.05 | .03 | 0.49 | 0.2 | 1.0 | 71 |
| rs9277535 | A/G | URD | Relapse | Recessive | 0.24 | .005 | 0.40 | 0.2 | 0.9 | 1 | 0.05 | .02 | 0.41 | 0.2 | 1.0 | 53 |
| rs9277542 | T/C | URD | Relapse | Recessive | 0.29 | .0008 | 0.39 | 0.2 | 0.7 | 1 | 0.05 | .01 | 0.45 | 0.2 | 0.9 | 73 |
P values in bold met prespecified statistical criteria for replication. Bf-C indicates the threshold P value after Bonferroni correction for the number of discovery signals in each cohort-endpoint combination.
Chr, chromosome; HR, hazard ratio; LB, lower boundary of the 95% confidence interval; MAF, minor allele frequency; SNP, single nucleotide polymorphism; UB, upper boundary of the 95% confidence interval; URD, unrelated.
Plus-strand major/minor alleles.
Minor allele frequency in the combined discovery and replication samples used for the evaluation.
Estimates represent the power to detect the discovery effect size at the 2-sided Bonferroni-corrected significance level using the observed replication standard error.