Table 5. Summary of GWAS results... | American Society of Hematology

Table 5.

Summary of GWAS results

Outcome, cohort, and genome	Number of discovery variants*	Number of discovery signals†	Number of replicated signals‡
aGVHD§
All donors	7	4	0
All recipients	155	9	0
10/10 HLA-matched sibling donors	28	7	0
10/10 HLA-matched sibling recipients	34	5	0
10/10 HLA-matched unrelated donors	8	3	0
10/10 HLA-matched unrelated recipients	13	8	0
cGVHD
All donors	3	1	0
All recipients	5	3	0
10/10 HLA-matched sibling donors	0	0	0
10/10 HLA-matched sibling recipients	8	2	1
10/10 HLA-matched unrelated donors	2	1	0
10/10 HLA-matched unrelated recipients	2	2	0
Relapse
All donors	1	1	0
All recipients	1	1	0
10/10 HLA-matched sibling donors	2	1	0
10/10 HLA-matched sibling recipients	3	2	0
10/10 HLA-matched unrelated donors	1	1	0
10/10 HLA-matched unrelated recipients	1	1	0

Outcome, cohort, and genome	Number of discovery variants*	Number of discovery signals†	Number of replicated signals‡
aGVHD§
All donors	7	4	0
All recipients	155	9	0
10/10 HLA-matched sibling donors	28	7	0
10/10 HLA-matched sibling recipients	34	5	0
10/10 HLA-matched unrelated donors	8	3	0
10/10 HLA-matched unrelated recipients	13	8	0
cGVHD
All donors	3	1	0
All recipients	5	3	0
10/10 HLA-matched sibling donors	0	0	0
10/10 HLA-matched sibling recipients	8	2	1
10/10 HLA-matched unrelated donors	2	1	0
10/10 HLA-matched unrelated recipients	2	2	0
Relapse
All donors	1	1	0
All recipients	1	1	0
10/10 HLA-matched sibling donors	2	1	0
10/10 HLA-matched sibling recipients	3	2	0
10/10 HLA-matched unrelated donors	1	1	0
10/10 HLA-matched unrelated recipients	1	1	0

P < 5 × 10⁻⁷.

Groups of variants with r² > 0.7.

Threshold P values corrected for the number of discovery signals.

Different subcategories of aGVHD associated with the same variant are counted only once.