Table 1.

Top 15 significant biological processes for the closest genes to TAp63 binding sites in primary CLL cells and MEC1 cells

Process−log10 (binomial P value)
Primary CLL cells Immune system process 10.46 
Fc-γ receptor signaling pathway involved in phagocytosis 7.93 
Fc-γ receptor signaling pathway 7.89 
Regulation of immune system process 7.84 
Fc receptor mediated stimulatory signaling pathway 7.8 
Positive regulation of immune system process 7.77 
DNA damage response-signal transduction by p53 class mediator 7.03 
Phagocytosis 6.82 
Multiorganism cellular process 6.77 
Symbiosis, encompassing mutualism through parasitism 6.7 
Interspecies interaction between organisms 6.68 
Signal transduction in response to DNA damage 6.59 
Immune response-activating signal transduction 6.55 
Mitotic G1 DNA damage checkpoint 6.54 
Response to other organism 6.51 
MEC1 cell line Immune response 21.03 
Cell activation 20.87 
Apoptotic process 18.49 
Leukocyte activation 17.72 
Response to other organism 16.98 
Programmed cell death 16.94 
Response to external biotic stimulus 16.76 
Positive regulation of cell activation 16.47 
Positive regulation of leukocyte activation 16.46 
Response to biotic stimulus 16.23 
Regulation of cell activation 16.02 
Regulation of leukocyte activation 15.44 
Positive regulation of immune system process 15 
Lymphocyte activation 14.72 
Regulation of lyphocyte activation 14.36 
Process−log10 (binomial P value)
Primary CLL cells Immune system process 10.46 
Fc-γ receptor signaling pathway involved in phagocytosis 7.93 
Fc-γ receptor signaling pathway 7.89 
Regulation of immune system process 7.84 
Fc receptor mediated stimulatory signaling pathway 7.8 
Positive regulation of immune system process 7.77 
DNA damage response-signal transduction by p53 class mediator 7.03 
Phagocytosis 6.82 
Multiorganism cellular process 6.77 
Symbiosis, encompassing mutualism through parasitism 6.7 
Interspecies interaction between organisms 6.68 
Signal transduction in response to DNA damage 6.59 
Immune response-activating signal transduction 6.55 
Mitotic G1 DNA damage checkpoint 6.54 
Response to other organism 6.51 
MEC1 cell line Immune response 21.03 
Cell activation 20.87 
Apoptotic process 18.49 
Leukocyte activation 17.72 
Response to other organism 16.98 
Programmed cell death 16.94 
Response to external biotic stimulus 16.76 
Positive regulation of cell activation 16.47 
Positive regulation of leukocyte activation 16.46 
Response to biotic stimulus 16.23 
Regulation of cell activation 16.02 
Regulation of leukocyte activation 15.44 
Positive regulation of immune system process 15 
Lymphocyte activation 14.72 
Regulation of lyphocyte activation 14.36 
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