IRs and HRs with 95% CIs of solid tumors and MDS/AML comparing lymphoma patients diagnosed 1993-2014, with follow-up through 2017, to matched population comparators in Sweden
| . | . | Solid tumors . | MDS/AML . | |||||
|---|---|---|---|---|---|---|---|---|
| Lymphoma patients, n (%) . | Comparators, n (%) . | Events, n* . | Rate* (per 1000 person-years) . | HR (95% CI)†,‡ . | Events, n* . | Rate* (per 10 000 person-years) . | HR (95% CI)†,‡ . | |
| Comparators | − | 160 498 (100) | 22 485 | 16.0 (15.8-16.2) | 1.00 (ref) | 363 | 2.4 (2.2-2.7) | 1.00 (ref) |
| Patients | 32 100 (100) | − | 3 619 | 20.6 (19.9-21.3) | 1.4 (1.4-1.5) | 217 | 11.3 (9.9-12.9) | 5.2 (4.4-6.2) |
| Sex | ||||||||
| Male | 17 691 (55.1) | 88 454 (55.1) | 2 242 | 23.8 (22.8-24.8) | 1.40 (1.3-1.5) | 127 | 12.2 (10.3-14.5) | 5.0 (4.0-6.3) |
| Female | 14 409 (44.9) | 72 044 (44.9) | 1 377 | 16.9 (16.0-17.8) | 1.5 (1.4-1.5) | 90 | 10.2 (8.3-12.5) | 5.5 (4.2-7.2) |
| P§ | .326 | .602 | ||||||
| Age at diagnosis/matching date | ||||||||
| <70 y | 15 672 (48.8) | 78 360 (48.8) | 1 909 | 15.9 (15.2-16.6) | 1.3 (1.2-1.4) | 140 | 10.8 (9.2-12.8) | 7.2 (5.7-9.1) |
| ≥70 y | 16 428 (51.2) | 82 138 (51.2) | 1 710 | 30.6 (29.1-32.0) | 1.4 (1.4-1.5) | 77 | 12.2 (9.8-15.3) | 3.4 (2.6-4.4) |
| P§ | .006 | <.001 | ||||||
| Year of diagnosis/matching date | ||||||||
| 1993-1999 | 8 924 (27.8) | 44 619 (27.8) | 1 150 | 19.6 (18.5-20.8) | 1.5 (1.4-1.6) | 78 | 12.1 (9.7-15.1) | 5.9 (4.4-7.7) |
| 2000-2004 | 6 969 (21.7) | 34 845 (21.7) | 912 | 20.2 (18.9-21.6) | 1.4 (1.3-1.5) | 57 | 11.5 (8.9-14.9) | 6.5 (4.6-9.1) |
| 2005-2009 | 7 577 (23.6) | 37 885 (23.6) | 844 | 20.2 (18.9-21.7) | 1.3 (1.2-1.4) | 45 | 9.9 (7.4-13.3) | 4.3 (3.0-6.2) |
| 2010-2014 | 8 630 (26.9) | 43 149 (26.9) | 713 | 23.5 (21.8-25.2) | 1.4 (1.3-1.6) | 37 | 11.1 (8.1-15.4) | 3.9 (2.6-5.9) |
| P§ | .064 | .154 | ||||||
| . | . | Solid tumors . | MDS/AML . | |||||
|---|---|---|---|---|---|---|---|---|
| Lymphoma patients, n (%) . | Comparators, n (%) . | Events, n* . | Rate* (per 1000 person-years) . | HR (95% CI)†,‡ . | Events, n* . | Rate* (per 10 000 person-years) . | HR (95% CI)†,‡ . | |
| Comparators | − | 160 498 (100) | 22 485 | 16.0 (15.8-16.2) | 1.00 (ref) | 363 | 2.4 (2.2-2.7) | 1.00 (ref) |
| Patients | 32 100 (100) | − | 3 619 | 20.6 (19.9-21.3) | 1.4 (1.4-1.5) | 217 | 11.3 (9.9-12.9) | 5.2 (4.4-6.2) |
| Sex | ||||||||
| Male | 17 691 (55.1) | 88 454 (55.1) | 2 242 | 23.8 (22.8-24.8) | 1.40 (1.3-1.5) | 127 | 12.2 (10.3-14.5) | 5.0 (4.0-6.3) |
| Female | 14 409 (44.9) | 72 044 (44.9) | 1 377 | 16.9 (16.0-17.8) | 1.5 (1.4-1.5) | 90 | 10.2 (8.3-12.5) | 5.5 (4.2-7.2) |
| P§ | .326 | .602 | ||||||
| Age at diagnosis/matching date | ||||||||
| <70 y | 15 672 (48.8) | 78 360 (48.8) | 1 909 | 15.9 (15.2-16.6) | 1.3 (1.2-1.4) | 140 | 10.8 (9.2-12.8) | 7.2 (5.7-9.1) |
| ≥70 y | 16 428 (51.2) | 82 138 (51.2) | 1 710 | 30.6 (29.1-32.0) | 1.4 (1.4-1.5) | 77 | 12.2 (9.8-15.3) | 3.4 (2.6-4.4) |
| P§ | .006 | <.001 | ||||||
| Year of diagnosis/matching date | ||||||||
| 1993-1999 | 8 924 (27.8) | 44 619 (27.8) | 1 150 | 19.6 (18.5-20.8) | 1.5 (1.4-1.6) | 78 | 12.1 (9.7-15.1) | 5.9 (4.4-7.7) |
| 2000-2004 | 6 969 (21.7) | 34 845 (21.7) | 912 | 20.2 (18.9-21.6) | 1.4 (1.3-1.5) | 57 | 11.5 (8.9-14.9) | 6.5 (4.6-9.1) |
| 2005-2009 | 7 577 (23.6) | 37 885 (23.6) | 844 | 20.2 (18.9-21.7) | 1.3 (1.2-1.4) | 45 | 9.9 (7.4-13.3) | 4.3 (3.0-6.2) |
| 2010-2014 | 8 630 (26.9) | 43 149 (26.9) | 713 | 23.5 (21.8-25.2) | 1.4 (1.3-1.6) | 37 | 11.1 (8.1-15.4) | 3.9 (2.6-5.9) |
| P§ | .064 | .154 | ||||||