Regimens used in the treatment of autoimmune cytopenias in lymphoma
| Abbreviation . | Therapy . | Dose . | References . |
|---|---|---|---|
| A | Alemtuzumab | 3-mg test dose, then 10-30 mg/wk for 4-6 wk | 43 |
| ATG | Anti-thymocyte globulin | 10-20 mg/kg for 10 d | 45 |
| Az | Azathioprine | 0.5 mg/kg initial up to 2-2.5 mg/kg day (max, 150 mg/d) | 21 |
| B | Bendamustine | 70 or 90 or 100 mg/every morning on days 1-2 every 4 wk | 28, 55, 59 |
| Bo | Bortezomib | 1.3 mg/wk for 1-4 wk | 21, 55, 61 |
| C | Cyclophosphamide | 1-2 mg/kg per day or 50-150 mg/d orally or 300-1000 mg IV on day 1 every 4 wk (eg, 750 mg per day) | 13, 22, 26, 30-31 |
| CsA | Cyclosporin A | 3-5 mg/kg per day | 19, 21 |
| ct/et | Clinical trials/experimental therapies | eg, ibrutinib 420 mg/d or venetoclax 400 mg/d after ramp-up weeks | 8, 20-21, 34-35, 41, 49, 55, 65 |
| D | Dexamethasone | 40 mg for 4 d (monotherapy) or 12 mg IV on days 1-2 and orally on days 3-7 (eg, combined with rituximab and cyclophosphamide) | 11-13, 21-22, 30-31, 69 |
| Da | Danazol | 200 mg 3-4 times per day | 21-22 |
| EPO | Epoetin α | 5 000-40 000 U/wk | 44-45 |
| F | Fludarabine | 40 mg every morning on days 1-5 or 25 mg every morning on days 1-3 | 22, 26, 55, 58 |
| GCSF | Granulocyte colony stimulating factor | 1-3 μg/kg per day | 91 |
| HSCT | Hematopoietic stem cell transplantation | — | — |
| IVIG | Intravenous immune globulin | 1-2 g/kg per day over 1-2 d (PRCA: 5 d) | 12-13, 19-20, |
| MMF | Mycophenolate mofetil | 600 mg/d, 2 times per day | 19, 21 |
| MTX | Methotrexate | 10 mg every morning weekly | 77 |
| P | Prednisone | 0.5-2 mg/kg per day for 4 wk, taper over 1-2 mo | 11-13, 21-22, 69 |
| R | Rituximab | 375 mg/every morning weekly for 4 wk (or 100 mg weekly or 1000 mg on the days 1 and 15) | 12-13, 19, 21-22, 28, 30-31, 55-56, 58-59, 69 |
| Su | Sutimlimab | 10 mg/kg test dose, 60 mg/kg 4 times per week starting 1-4 d after test dose | 55, 65 |
| TPO-RAs | Thrombopoietin receptor agonists | Eltrombopag 50-150 mg/d, romiplostim 1-10 μg/kg per week | 69-70, 92 |
| V | Vincristine | 1 mg/wk for 4-6 wk | 19, 32 |
| Abbreviation . | Therapy . | Dose . | References . |
|---|---|---|---|
| A | Alemtuzumab | 3-mg test dose, then 10-30 mg/wk for 4-6 wk | 43 |
| ATG | Anti-thymocyte globulin | 10-20 mg/kg for 10 d | 45 |
| Az | Azathioprine | 0.5 mg/kg initial up to 2-2.5 mg/kg day (max, 150 mg/d) | 21 |
| B | Bendamustine | 70 or 90 or 100 mg/every morning on days 1-2 every 4 wk | 28, 55, 59 |
| Bo | Bortezomib | 1.3 mg/wk for 1-4 wk | 21, 55, 61 |
| C | Cyclophosphamide | 1-2 mg/kg per day or 50-150 mg/d orally or 300-1000 mg IV on day 1 every 4 wk (eg, 750 mg per day) | 13, 22, 26, 30-31 |
| CsA | Cyclosporin A | 3-5 mg/kg per day | 19, 21 |
| ct/et | Clinical trials/experimental therapies | eg, ibrutinib 420 mg/d or venetoclax 400 mg/d after ramp-up weeks | 8, 20-21, 34-35, 41, 49, 55, 65 |
| D | Dexamethasone | 40 mg for 4 d (monotherapy) or 12 mg IV on days 1-2 and orally on days 3-7 (eg, combined with rituximab and cyclophosphamide) | 11-13, 21-22, 30-31, 69 |
| Da | Danazol | 200 mg 3-4 times per day | 21-22 |
| EPO | Epoetin α | 5 000-40 000 U/wk | 44-45 |
| F | Fludarabine | 40 mg every morning on days 1-5 or 25 mg every morning on days 1-3 | 22, 26, 55, 58 |
| GCSF | Granulocyte colony stimulating factor | 1-3 μg/kg per day | 91 |
| HSCT | Hematopoietic stem cell transplantation | — | — |
| IVIG | Intravenous immune globulin | 1-2 g/kg per day over 1-2 d (PRCA: 5 d) | 12-13, 19-20, |
| MMF | Mycophenolate mofetil | 600 mg/d, 2 times per day | 19, 21 |
| MTX | Methotrexate | 10 mg every morning weekly | 77 |
| P | Prednisone | 0.5-2 mg/kg per day for 4 wk, taper over 1-2 mo | 11-13, 21-22, 69 |
| R | Rituximab | 375 mg/every morning weekly for 4 wk (or 100 mg weekly or 1000 mg on the days 1 and 15) | 12-13, 19, 21-22, 28, 30-31, 55-56, 58-59, 69 |
| Su | Sutimlimab | 10 mg/kg test dose, 60 mg/kg 4 times per week starting 1-4 d after test dose | 55, 65 |
| TPO-RAs | Thrombopoietin receptor agonists | Eltrombopag 50-150 mg/d, romiplostim 1-10 μg/kg per week | 69-70, 92 |
| V | Vincristine | 1 mg/wk for 4-6 wk | 19, 32 |