Statistical analysis of the bleeding time and blood loss in mice with various VWF genotypes using TTT bleeding test
| Two-way ANOVA Multiple comparisons of mice with various VWF genotypes . | Bleeding time (minutes) . | Blood loss (volume) . | ||
|---|---|---|---|---|
| Primary (P) . | Rechallenge (P) . | Primary (P) . | Rechallenge (P) . | |
| C57BL/6J vs VWF+/+ | .5929 | .5003 | .8962 | .8308 |
| C57BL/6J vs VWF2N/+ | .4209 | .2956 | .1783 | .1879 |
| C57BL/6J vs VWF2N/2N | .0175* | .0107* | .0001*** | .0209* |
| C57BL/6J vs VWF2N/− | .0788 | .6932 | .3813 | .8563 |
| C57BL/6J vs VWF−/− | .0551 | .0011** | .7122 | .0430* |
| C57BL/6J vs VWF+/− | .4009 | .4441 | .7818 | .7962 |
| VWF+/+ vs VWF2N/+ | .1983 | .0999 | .1622 | .1468 |
| VWF+/+ vs VWF2N/2N | .0062** | .0025** | .0002*** | .0172* |
| VWF+/+ vs VWF2N/− | .0302* | .2973 | .3397 | .7008 |
| VWF+/+ vs VWF−/− | .0206* | .0003*** | .6326 | .0345* |
| VWF+/+ vs VWF+/− | .7955 | .9616 | .8960 | .9762 |
| VWF2N/+ vs VWF2N/2N | .1068 | .1185 | .0079** | .3001 |
| VWF2N/+ vs VWF2N/− | .3313 | .5124 | .6324 | .2545 |
| VWF2N/+ vs VWF−/− | .2553 | .0209* | .3251 | .4633 |
| VWF2N/+ vs VWF+/− | .1032 | .0732 | .1064 | .1169 |
| VWF2N/2N vs VWF2N/− | .5124 | .0288* | .0020** | .0322* |
| VWF2N/2N vs VWF−/− | .6260 | .4311 | .0004*** | .7595 |
| VWF2N/2N vs VWF+/− | .0017** | .0012** | <.0001**** | .0108* |
| VWF2N/- vs VWF−/− | .8662 | .0037** | .6108 | .0641 |
| VWF2N/- vs VWF+/− | .0109* | .2481 | .2507 | .6606 |
| VWF−/− vs VWF+/− | .0069** | <.0001**** | .5190 | .0235* |
| Two-way ANOVA Multiple comparisons of mice with various VWF genotypes . | Bleeding time (minutes) . | Blood loss (volume) . | ||
|---|---|---|---|---|
| Primary (P) . | Rechallenge (P) . | Primary (P) . | Rechallenge (P) . | |
| C57BL/6J vs VWF+/+ | .5929 | .5003 | .8962 | .8308 |
| C57BL/6J vs VWF2N/+ | .4209 | .2956 | .1783 | .1879 |
| C57BL/6J vs VWF2N/2N | .0175* | .0107* | .0001*** | .0209* |
| C57BL/6J vs VWF2N/− | .0788 | .6932 | .3813 | .8563 |
| C57BL/6J vs VWF−/− | .0551 | .0011** | .7122 | .0430* |
| C57BL/6J vs VWF+/− | .4009 | .4441 | .7818 | .7962 |
| VWF+/+ vs VWF2N/+ | .1983 | .0999 | .1622 | .1468 |
| VWF+/+ vs VWF2N/2N | .0062** | .0025** | .0002*** | .0172* |
| VWF+/+ vs VWF2N/− | .0302* | .2973 | .3397 | .7008 |
| VWF+/+ vs VWF−/− | .0206* | .0003*** | .6326 | .0345* |
| VWF+/+ vs VWF+/− | .7955 | .9616 | .8960 | .9762 |
| VWF2N/+ vs VWF2N/2N | .1068 | .1185 | .0079** | .3001 |
| VWF2N/+ vs VWF2N/− | .3313 | .5124 | .6324 | .2545 |
| VWF2N/+ vs VWF−/− | .2553 | .0209* | .3251 | .4633 |
| VWF2N/+ vs VWF+/− | .1032 | .0732 | .1064 | .1169 |
| VWF2N/2N vs VWF2N/− | .5124 | .0288* | .0020** | .0322* |
| VWF2N/2N vs VWF−/− | .6260 | .4311 | .0004*** | .7595 |
| VWF2N/2N vs VWF+/− | .0017** | .0012** | <.0001**** | .0108* |
| VWF2N/- vs VWF−/− | .8662 | .0037** | .6108 | .0641 |
| VWF2N/- vs VWF+/− | .0109* | .2481 | .2507 | .6606 |
| VWF−/− vs VWF+/− | .0069** | <.0001**** | .5190 | .0235* |
P < .05; **P < .01; ***P < .001; ****P < .0001.