Table 5. Characteristic IHC phenotype of... | American Society of Hematology

Table 5.

Characteristic IHC phenotype of histiocytic disorders

IHC Marker	LCH	RDD	ECD
CD68	+	+	+
CD163	−*	+†	+
Cyclin D1	+	+	+
S100	+	+	±‡
OCT2	−*	+‖	−
Factor XIIIa	−	±§	+‖
CD1a	+‖	−	−
CD207/langerin	+‖	−	−
ZBTB46	+‖	−	−

IHC Marker	LCH	RDD	ECD
CD68	+	+	+
CD163	−*	+†	+
Cyclin D1	+	+	+
S100	+	+	±‡
OCT2	−*	+‖	−
Factor XIIIa	−	±§	+‖
CD1a	+‖	−	−
CD207/langerin	+‖	−	−
ZBTB46	+‖	−	−

Key differences in the phenotypes of each histiocytic disorder.

OCT2 and CD163 are expressed in a minority of LCH cases (5-10%).

CD163 is negative in a minority of RDD cases (∼10%).

S100 is expressed in ∼20-30% of ECD cases.

Factor XIIIa expression is increased in 30% of RDD cases.