Table 2.

Analysis of associations of grade 3 or 4 adverse events from diagnosis to the end of induction 2 and in subsequent therapies with decreases in Z-scores for body mass index and weight during induction and with Z-scores at diagnosis

Reported adverse eventsBody mass index
Decrease in Z-score from diagnosis to induction 2Z-score at diagnosis
Before induction 2NHR95% CIPHR95% CIP
 Cardiovascular 26 1.16 0.60-2.26 .662 1.16 0.87-1.55 .321 
 Gastrointestinal 76 1.08 0.75-1.56 .675 0.95 0.78-1.17 .646 
  Anorexia/nausea/vomiting 22 0.84 0.45-1.58 .597 0.91 0.62-1.33 .625 
  Colitis/typhlitis 31 0.83 0.46-1.49 .527 1.24 0.96-1.61 .095 
  Diarrhea 13 1.15 0.50-2.64 .742 1.05 0.77-1.42 .764 
  Mucositis 18 1.28 0.51-3.23 .605 1.19 0.85-1.66 .319 
 Hemorrhage 25 0.86 0.60-1.23 .419 1.38 1.12-1.70 .003* 
 Hepatic 37 1.33 0.91-1.94 .139 0.81 0.59-1.10 .174 
 Infection/febrile neutropenia 186 1.04 0.88-1.23 .618 0.97 0.86-1.09 .576 
 Respiratory 32 1.50 0.72-3.12 .275 1.06 0.82-1.37 .672 
 Neurologic/psychiatric 14 0.74 0.34-1.64 .459 0.93 0.66-1.32 .685 
After induction 2        
 Cardiovascular 12 1.34 0.69-2.60 .381 1.36 0.81-2.28 .237 
 Gastrointestinal 44 1.14 0.73-1.79 .564 1.13 0.91-1.40 .281 
  Anorexia/nausea/vomiting 15 0.72 0.33-1.58 .414 1.28 0.96-1.70 .088 
  Colitis/typhlitis 20 1.12 0.56-2.24 .751 1.10 0.75-1.62 .621 
  Diarrhea 9 1.31 0.26-6.71 .746 1.34 0.87-2.06 .019 
  Mucositis 4 1.59 0.67-3.76 .289 0.80 0.29-2.22 .662 
 Hemorrhage 17 1.15 0.77-1.72 .500 0.81 0.57-1.15 .235 
 Hepatic 19 1.69 0.85-3.38 .138 1.10 0.73-1.64 .655 
 Infection/febrile neutropenia 144 1.12 0.86-1.45 .402 1.05 0.91-1.21 .499 
 Respiratory 19 1.29 0.56-2.95 .551 1.69 1.17-2.43 .005* 
 Neurologic/psychiatric 13 0.79 0.25-2.49 .691 1.17 0.84-1.61 .360 
Reported adverse eventsBody mass index
Decrease in Z-score from diagnosis to induction 2Z-score at diagnosis
Before induction 2NHR95% CIPHR95% CIP
 Cardiovascular 26 1.16 0.60-2.26 .662 1.16 0.87-1.55 .321 
 Gastrointestinal 76 1.08 0.75-1.56 .675 0.95 0.78-1.17 .646 
  Anorexia/nausea/vomiting 22 0.84 0.45-1.58 .597 0.91 0.62-1.33 .625 
  Colitis/typhlitis 31 0.83 0.46-1.49 .527 1.24 0.96-1.61 .095 
  Diarrhea 13 1.15 0.50-2.64 .742 1.05 0.77-1.42 .764 
  Mucositis 18 1.28 0.51-3.23 .605 1.19 0.85-1.66 .319 
 Hemorrhage 25 0.86 0.60-1.23 .419 1.38 1.12-1.70 .003* 
 Hepatic 37 1.33 0.91-1.94 .139 0.81 0.59-1.10 .174 
 Infection/febrile neutropenia 186 1.04 0.88-1.23 .618 0.97 0.86-1.09 .576 
 Respiratory 32 1.50 0.72-3.12 .275 1.06 0.82-1.37 .672 
 Neurologic/psychiatric 14 0.74 0.34-1.64 .459 0.93 0.66-1.32 .685 
After induction 2        
 Cardiovascular 12 1.34 0.69-2.60 .381 1.36 0.81-2.28 .237 
 Gastrointestinal 44 1.14 0.73-1.79 .564 1.13 0.91-1.40 .281 
  Anorexia/nausea/vomiting 15 0.72 0.33-1.58 .414 1.28 0.96-1.70 .088 
  Colitis/typhlitis 20 1.12 0.56-2.24 .751 1.10 0.75-1.62 .621 
  Diarrhea 9 1.31 0.26-6.71 .746 1.34 0.87-2.06 .019 
  Mucositis 4 1.59 0.67-3.76 .289 0.80 0.29-2.22 .662 
 Hemorrhage 17 1.15 0.77-1.72 .500 0.81 0.57-1.15 .235 
 Hepatic 19 1.69 0.85-3.38 .138 1.10 0.73-1.64 .655 
 Infection/febrile neutropenia 144 1.12 0.86-1.45 .402 1.05 0.91-1.21 .499 
 Respiratory 19 1.29 0.56-2.95 .551 1.69 1.17-2.43 .005* 
 Neurologic/psychiatric 13 0.79 0.25-2.49 .691 1.17 0.84-1.61 .360 
Reported adverse eventsWeight
Decrease in Z-score from diagnosis to induction 2Z-score at diagnosis
Before induction 2NHR95% CIPHR95% CIP
 Cardiovascular 26 1.47 0.73-2.95 .278 1.06 0.80-1.41 .683 
 Gastrointestinal 76 1.54 1.11-2.14 .010* 0.90 0.73-1.12 .349 
  Anorexia/nausea/vomiting 22 1.27 0.78-2.08 .339 0.84 0.56-1.25 .385 
  Colitis/typhlitis 31 1.00 0.57-1.73 .987 1.17 0.88-1.54 .278 
  Diarrhea 13 2.04 0.87-4.76 .101 1.18 0.88-1.57 .268 
  Mucositis 18 2.23 1.37-3.60 <.001* 1.25 0.94-1.66 .127 
 Hemorrhage 25 0.87 0.54-1.42 .579 1.36 1.13-1.64 <.001* 
 Hepatic 37 1.27 0.82-1.96 .280 0.84 0.63-1.12 .229 
 Infection/febrile neutropenia 186 1.16 0.94-1.42 .154 0.96 0.87-1.07 .491 
 Respiratory 32 1.54 0.85-2.78 .154 1.01 0.75-1.36 .949 
 Neurologic/psychiatric 14 0.59 0.21-1.63 .308 0.80 0.59-1.09 .164 
After induction 2        
 Cardiovascular 12 1.27 0.53-3.06 .589 1.36 0.84-2.20 .205 
 Gastrointestinal 44 1.69 1.13-2.53 .010* 1.08 0.86-1.35 .515 
  Anorexia/nausea/vomiting 15 1.19 0.59-2.42 .625 1.18 0.93-1.51 .173 
  Colitis/typhlitis 20 1.04 0.45-2.40 .927 1.19 0.84-1.68 .327 
  Diarrhea 9 2.78 1.51-5.13 .001* 1.16 0.67-1.99 .601 
  Mucositis 4 3.40 1.05-11.11 .042* 0.58 0.09-3.59 .554 
 Hemorrhage 17 0.79 0.39-1.60 .520 0.86 0.59-1.25 .418 
 Hepatic 19 2.27 1.24-4.13 .008* 1.12 0.78-1.60 .541 
 Infection/febrile neutropenia 144 1.38 1.06-1.81 .018* 1.00 0.87-1.15 .976 
 Respiratory 19 1.78 0.99-3.22 .056 1.57 1.17-2.11 .003* 
 Neurologic/psychiatric 13 1.04 0.39-2.75 .943 1.19 0.87-1.64 .283 
 
Reported adverse eventsWeight
Decrease in Z-score from diagnosis to induction 2Z-score at diagnosis
Before induction 2NHR95% CIPHR95% CIP
 Cardiovascular 26 1.47 0.73-2.95 .278 1.06 0.80-1.41 .683 
 Gastrointestinal 76 1.54 1.11-2.14 .010* 0.90 0.73-1.12 .349 
  Anorexia/nausea/vomiting 22 1.27 0.78-2.08 .339 0.84 0.56-1.25 .385 
  Colitis/typhlitis 31 1.00 0.57-1.73 .987 1.17 0.88-1.54 .278 
  Diarrhea 13 2.04 0.87-4.76 .101 1.18 0.88-1.57 .268 
  Mucositis 18 2.23 1.37-3.60 <.001* 1.25 0.94-1.66 .127 
 Hemorrhage 25 0.87 0.54-1.42 .579 1.36 1.13-1.64 <.001* 
 Hepatic 37 1.27 0.82-1.96 .280 0.84 0.63-1.12 .229 
 Infection/febrile neutropenia 186 1.16 0.94-1.42 .154 0.96 0.87-1.07 .491 
 Respiratory 32 1.54 0.85-2.78 .154 1.01 0.75-1.36 .949 
 Neurologic/psychiatric 14 0.59 0.21-1.63 .308 0.80 0.59-1.09 .164 
After induction 2        
 Cardiovascular 12 1.27 0.53-3.06 .589 1.36 0.84-2.20 .205 
 Gastrointestinal 44 1.69 1.13-2.53 .010* 1.08 0.86-1.35 .515 
  Anorexia/nausea/vomiting 15 1.19 0.59-2.42 .625 1.18 0.93-1.51 .173 
  Colitis/typhlitis 20 1.04 0.45-2.40 .927 1.19 0.84-1.68 .327 
  Diarrhea 9 2.78 1.51-5.13 .001* 1.16 0.67-1.99 .601 
  Mucositis 4 3.40 1.05-11.11 .042* 0.58 0.09-3.59 .554 
 Hemorrhage 17 0.79 0.39-1.60 .520 0.86 0.59-1.25 .418 
 Hepatic 19 2.27 1.24-4.13 .008* 1.12 0.78-1.60 .541 
 Infection/febrile neutropenia 144 1.38 1.06-1.81 .018* 1.00 0.87-1.15 .976 
 Respiratory 19 1.78 0.99-3.22 .056 1.57 1.17-2.11 .003* 
 Neurologic/psychiatric 13 1.04 0.39-2.75 .943 1.19 0.87-1.64 .283 
 

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