Patient demographics and comorbidities
| Enrollment . | Patients (n = 8288) . |
|---|---|
| SAMe-TT2R2 ≥2 | 4693 (56.6) |
| Female, n (%) | 3952 (47.7) |
| Age <60 y, n (%) | 2515 (30.3) |
| Non-White,* n (%) | 1429/7869 (18.2) |
| Medical history (≥2), n (%) | 4319 (52.1) |
| Hypertension | 5458 (65.9) |
| CAD/MI† | 2517 (30.4) |
| Diabetes mellitus | 2115 (25.5) |
| CHF‡ | 1622 (19.6) |
| CRI§ | 1153 (13.9) |
| Stroke | 1005 (12.1) |
| PAD∥ | 514 (6.2) |
| Chronic liver disease | 179 (2.2) |
| Treatment,¶ n (%) | 1233 (14.9) |
| Current tobacco use, n (%) | 674 (8.1) |
| Enrollment . | Patients (n = 8288) . |
|---|---|
| SAMe-TT2R2 ≥2 | 4693 (56.6) |
| Female, n (%) | 3952 (47.7) |
| Age <60 y, n (%) | 2515 (30.3) |
| Non-White,* n (%) | 1429/7869 (18.2) |
| Medical history (≥2), n (%) | 4319 (52.1) |
| Hypertension | 5458 (65.9) |
| CAD/MI† | 2517 (30.4) |
| Diabetes mellitus | 2115 (25.5) |
| CHF‡ | 1622 (19.6) |
| CRI§ | 1153 (13.9) |
| Stroke | 1005 (12.1) |
| PAD∥ | 514 (6.2) |
| Chronic liver disease | 179 (2.2) |
| Treatment,¶ n (%) | 1233 (14.9) |
| Current tobacco use, n (%) | 674 (8.1) |
CAD/MI, XXX; CRI, XXX; CHF, XXX; PAD, XXX.
Race was self-reported based on medical charts.
Coronary artery disease/myocardial infarction.
Congestive heart failure.
Chronic renal insufficiency.
Peripheral artery disease.
Concurrent use of interacting medication: fluconazole, amiodarone, Bactrim, Flagyl, carbamazepine, phenobarbital, primidone, phenytoin, and rifampin.