Multistate model on the impact of LA stability on the risks of thrombosis and death
| . | . | Univariable analysis . | Multivariable analysis* . | ||||
|---|---|---|---|---|---|---|---|
| Transition . | Outcome . | Transition hazard ratio . | 95% CI . | P . | Transition hazard ratio . | 95% CI . | P . |
| First negative LA test | ATE | 0.21 | 0.03-1.56 | .127 | 0.56 | 0.07-4.71 | .596 |
| First negative LA test | VTE | 1.26 | 0.46-3.46 | .649 | 1.16 | 0.40-3.32 | .786 |
| First negative LA test | Total thrombosis | 0.86 | 0.36-2.08 | .744 | 1.14 | 0.45-2.93 | .783 |
| First negative LA test | Death | 1.39 | 0.57-3.39 | .470 | 2.04 | 0.71-5.82 | .183 |
| . | . | Univariable analysis . | Multivariable analysis* . | ||||
|---|---|---|---|---|---|---|---|
| Transition . | Outcome . | Transition hazard ratio . | 95% CI . | P . | Transition hazard ratio . | 95% CI . | P . |
| First negative LA test | ATE | 0.21 | 0.03-1.56 | .127 | 0.56 | 0.07-4.71 | .596 |
| First negative LA test | VTE | 1.26 | 0.46-3.46 | .649 | 1.16 | 0.40-3.32 | .786 |
| First negative LA test | Total thrombosis | 0.86 | 0.36-2.08 | .744 | 1.14 | 0.45-2.93 | .783 |
| First negative LA test | Death | 1.39 | 0.57-3.39 | .470 | 2.04 | 0.71-5.82 | .183 |
Results were obtained with a unidirectional “illness-death” model. P, Wald test P value.
Model adjusted for 3 variables previously included in a lupus anticoagulant thrombosis risk score (active smoking, lupus-sensitive aPTT, and diabetes), as well VKA use at baseline (the strongest determinant of LA stability) and age (strong epidemiologic determinant of [arterial] thrombosis and mortality).