Table 3.

Associations between Khorana score levels and risk components and 6-month risk of VTE in a subdistribution hazard model

Subdistribution hazard ratios*
CrudeAdjusted
Khorana component 
 Pancreas 2.06 (1.64-2.59) 2.05 (1.63-2.58) 
 Stomach 2.23 (1.74-2.87) 2.25 (1.76-2.89) 
 Lung 1.36 (1.17-1.59) 1.26 (1.08-1.48) 
 Lymphoma 1.13 (0.91-1.41) 1.10 (0.88-1.37) 
 Gynecologic 1.18 (0.94-1.49) 1.19 (0.94-1.50) 
 Bladder 2.17 (1.58-2.98) 2.12 (1.55-2.92) 
 Testis 1.04 (0.54-2.01) 1.12 (0.58-2.15) 
Hemoglobin level <10 g/dL or use of erythropoiesis-stimulating agents 1.19 (0.97-1.46) 1.13 (0.91-1.39) 
Platelet count ≥350 × 109/L 1.15 (1.01-1.31) 0.94 (0.82-1.08) 
Leukocyte count >11 × 109/L 1.73 (1.51-1.99) 1.63 (1.41-1.88) 
Body mass index ≥35 kg/m2 1.30 (0.78-2.17) 1.33 (0.79-2.22) 
Khorana score level 
 0 Ref.  
 1 1.69 (1.42-2.01)  
 2 2.29 (1.92-2.74)  
 3 2.68 (2.17-3.32)  
 4 3.29 (2.28-4.72)  
 5-6 5.66 (2.30-13.93)  
Subdistribution hazard ratios*
CrudeAdjusted
Khorana component 
 Pancreas 2.06 (1.64-2.59) 2.05 (1.63-2.58) 
 Stomach 2.23 (1.74-2.87) 2.25 (1.76-2.89) 
 Lung 1.36 (1.17-1.59) 1.26 (1.08-1.48) 
 Lymphoma 1.13 (0.91-1.41) 1.10 (0.88-1.37) 
 Gynecologic 1.18 (0.94-1.49) 1.19 (0.94-1.50) 
 Bladder 2.17 (1.58-2.98) 2.12 (1.55-2.92) 
 Testis 1.04 (0.54-2.01) 1.12 (0.58-2.15) 
Hemoglobin level <10 g/dL or use of erythropoiesis-stimulating agents 1.19 (0.97-1.46) 1.13 (0.91-1.39) 
Platelet count ≥350 × 109/L 1.15 (1.01-1.31) 0.94 (0.82-1.08) 
Leukocyte count >11 × 109/L 1.73 (1.51-1.99) 1.63 (1.41-1.88) 
Body mass index ≥35 kg/m2 1.30 (0.78-2.17) 1.33 (0.79-2.22) 
Khorana score level 
 0 Ref.  
 1 1.69 (1.42-2.01)  
 2 2.29 (1.92-2.74)  
 3 2.68 (2.17-3.32)  
 4 3.29 (2.28-4.72)  
 5-6 5.66 (2.30-13.93)  
*

Based on the Fine and Gray regression model using time since initiation of chemotherapy as underlying time scale.

Adjusted for other Khorana score components.

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