Multivariable RR of impairment (and 95% CI) in neurocognition, emotional distress, and quality of life associated with demographic and clinical factors
| Characteristic . | Neurocognitive . | Emotional distress . | ||||
|---|---|---|---|---|---|---|
| Task efficiency (n = 1388) RR (95% CI) . | Emotional regulation (n = 1415) RR (95% CI) . | Organization (n = 1414) RR (95% CI) . | Memory (n = 1413) RR (95% CI) . | Anxiety (n = 1466) RR (95% CI) . | Depression (n = 1467) RR (95% CI) . | |
| Female sex (vs male) | 1.15 (0.84-1.57) | 1.42 (1.11-1.82) | 0.89 (0.66-1.19) | 1.98 (1.34-2.94) | 0.68 (0.46-1.00) | 0.87 (0.62-1.22) |
| Other race (vs white) | 1.67 (1.07-2.62) | 1.40 (0.94-2.10) | 1.19 (0.73-1.94) | 1.44 (0.81-2.55) | 0.95 (0.46-1.95) | 1.40 (0.82-2.39) |
| Former smoker (vs never) | 1.45 (1.01-2.08) | 1.33 (1.00-1.77) | 1.01 (0.70-1.45) | 1.76 (1.16-2.67) | 1.83 (1.17-2.86) | 1.49 (0.98-2.26) |
| Current smoker (vs never) | 1.56 (1.02-2.39) | 1.84 (1.35-2.49) | 1.05 (0.67-1.64) | 1.46 (0.87-2.47) | 2.43 (1.51-3.93) | 2.73 (1.85-4.04) |
| Meet CDC exercise guidelines (yes vs no) | 0.70 (0.52-0.95) | 0.95 (0.75-1.19) | 0.60 (0.45-0.80) | 0.88 (0.61-1.27) | 0.87 (0.59-1.29) | 0.66 (0.48-0.92) |
| Overweight BMI (vs normal/underweight) | 1.33 (0.94-1.90) | 1.05 (0.79-1.40) | 1.17 (0.84-1.64) | 1.15 (0.74-1.78) | 1.33 (0.89-2.01) | 1.26 (0.87-1.83) |
| Obese BMI (vs normal/underweight) | 1.39 (0.95-2.03) | 1.64 (1.26-2.13) | 1.24 (0.87-1.78) | 1.61 (1.04-2.47) | 0.92 (0.55-1.53) | 1.18 (0.77-1.79) |
| Relapse/subsequent malignancy (yes vs no) | 1.65 (1.18-2.31) | 1.17 (0.88-1.54) | 1.42 (1.01-2.01) | 1.16 (0.77-1.75) | 1.28 (0.81-2.01) | 1.24 (0.83-1.85) |
| Anthracycline (yes vs no) | 1.10 (0.71-1.71) | 0.56 (0.38-0.82) | 0.70 (0.44-1.10) | 1.25 (0.69-2.24) | 0.62 (0.33-1.16) | 0.73 (0.42-1.26) |
| Bleomycin (yes vs no) | 0.79 (0.52-1.21) | 0.98 (0.67-1.42) | 1.31 (0.87-1.99) | 1.05 (0.61-1.81) | 1.34 (0.74-2.41) | 1.27 (0.75-2.16) |
| Corticosteroids (yes vs no) | 1.01 (0.67-1.53) | 0.98 (0.71-1.35) | 1.57 (1.02-2.42) | 0.87 (0.51-1.47) | 1.99 (1.13-3.50) | 1.49 (0.91-2.44) |
| Chest radiation (yes vs no) | 1.05 (0.71-1.54) | 1.11 (0.81-1.51) | 0.98 (0.68-1.39) | 1.13 (0.73-1.75) | 0.94 (0.60-1.47) | 0.86 (0.58-1.28) |
| Alkylating agents (yes vs no) | 1.31 (0.86-2.01) | 1.34 (0.96-1.87) | 0.61 (0.40-0.92) | 0.97 (0.57-1.64) | 0.94 (0.54-1.64) | 1.05 (0.63-1.73) |
| Characteristic . | Neurocognitive . | Emotional distress . | ||||
|---|---|---|---|---|---|---|
| Task efficiency (n = 1388) RR (95% CI) . | Emotional regulation (n = 1415) RR (95% CI) . | Organization (n = 1414) RR (95% CI) . | Memory (n = 1413) RR (95% CI) . | Anxiety (n = 1466) RR (95% CI) . | Depression (n = 1467) RR (95% CI) . | |
| Female sex (vs male) | 1.15 (0.84-1.57) | 1.42 (1.11-1.82) | 0.89 (0.66-1.19) | 1.98 (1.34-2.94) | 0.68 (0.46-1.00) | 0.87 (0.62-1.22) |
| Other race (vs white) | 1.67 (1.07-2.62) | 1.40 (0.94-2.10) | 1.19 (0.73-1.94) | 1.44 (0.81-2.55) | 0.95 (0.46-1.95) | 1.40 (0.82-2.39) |
| Former smoker (vs never) | 1.45 (1.01-2.08) | 1.33 (1.00-1.77) | 1.01 (0.70-1.45) | 1.76 (1.16-2.67) | 1.83 (1.17-2.86) | 1.49 (0.98-2.26) |
| Current smoker (vs never) | 1.56 (1.02-2.39) | 1.84 (1.35-2.49) | 1.05 (0.67-1.64) | 1.46 (0.87-2.47) | 2.43 (1.51-3.93) | 2.73 (1.85-4.04) |
| Meet CDC exercise guidelines (yes vs no) | 0.70 (0.52-0.95) | 0.95 (0.75-1.19) | 0.60 (0.45-0.80) | 0.88 (0.61-1.27) | 0.87 (0.59-1.29) | 0.66 (0.48-0.92) |
| Overweight BMI (vs normal/underweight) | 1.33 (0.94-1.90) | 1.05 (0.79-1.40) | 1.17 (0.84-1.64) | 1.15 (0.74-1.78) | 1.33 (0.89-2.01) | 1.26 (0.87-1.83) |
| Obese BMI (vs normal/underweight) | 1.39 (0.95-2.03) | 1.64 (1.26-2.13) | 1.24 (0.87-1.78) | 1.61 (1.04-2.47) | 0.92 (0.55-1.53) | 1.18 (0.77-1.79) |
| Relapse/subsequent malignancy (yes vs no) | 1.65 (1.18-2.31) | 1.17 (0.88-1.54) | 1.42 (1.01-2.01) | 1.16 (0.77-1.75) | 1.28 (0.81-2.01) | 1.24 (0.83-1.85) |
| Anthracycline (yes vs no) | 1.10 (0.71-1.71) | 0.56 (0.38-0.82) | 0.70 (0.44-1.10) | 1.25 (0.69-2.24) | 0.62 (0.33-1.16) | 0.73 (0.42-1.26) |
| Bleomycin (yes vs no) | 0.79 (0.52-1.21) | 0.98 (0.67-1.42) | 1.31 (0.87-1.99) | 1.05 (0.61-1.81) | 1.34 (0.74-2.41) | 1.27 (0.75-2.16) |
| Corticosteroids (yes vs no) | 1.01 (0.67-1.53) | 0.98 (0.71-1.35) | 1.57 (1.02-2.42) | 0.87 (0.51-1.47) | 1.99 (1.13-3.50) | 1.49 (0.91-2.44) |
| Chest radiation (yes vs no) | 1.05 (0.71-1.54) | 1.11 (0.81-1.51) | 0.98 (0.68-1.39) | 1.13 (0.73-1.75) | 0.94 (0.60-1.47) | 0.86 (0.58-1.28) |
| Alkylating agents (yes vs no) | 1.31 (0.86-2.01) | 1.34 (0.96-1.87) | 0.61 (0.40-0.92) | 0.97 (0.57-1.64) | 0.94 (0.54-1.64) | 1.05 (0.63-1.73) |
| Characteristic . | Quality of life . | |||||||
|---|---|---|---|---|---|---|---|---|
| General health (n = 1423) RR (95% CI) . | Physical function (n = 1548) RR (95% CI) . | Physical role limitation (n = 1545) RR (95% CI) . | Pain (n = 1549) RR (95% CI) . | Emotional role limitation (n = 1539) RR (95% CI) . | Vitality (n = 1427) RR (95% CI) . | Social functioning (n = 1551) RR (95% CI) . | Mental health (n = 1426) RR (95% CI) . | |
| Female sex (vs male) | 1.22 (1.03-1.44) | 1.58 (1.16-2.13) | 1.12 (0.88-1.43) | 1.31 (1.04-1.66) | 1.38 (1.08-1.77) | 1.56 (1.27-1.93) | 1.57 (1.20-2.05) | 1.37 (1.06-1.75) |
| Other race (vs white) | 0.90 (0.65-1.24) | 1.28 (0.77-2.11) | 1.45 (0.99-2.12) | 0.86 (0.53-1.39) | 1.62 (1.11-2.36) | 1.12 (0.79-1.58) | 1.43 (0.96-2.12) | 1.40 (0.95-2.07) |
| Former smoker (vs never) | 1.08 (0.88-1.32) | 1.31 (0.93-1.83) | 1.18 (0.90-1.55) | 1.22 (0.93-1.61) | 1.64 (1.24-2.17) | 1.23 (0.98-1.55) | 1.31 (0.96-1.78) | 1.54 (1.15-2.06) |
| Current smoker (vs never) | 1.39 (1.12-1.73) | 1.49 (1.00-2.20) | 1.47 (1.07-2.03) | 2.01 (1.52-2.65) | 1.93 (1.42-2.63) | 1.43 (1.10-1.86) | 1.78 (1.28-2.47) | 2.40 (1.80-3.18) |
| Meet CDC exercise guidelines (yes vs no) | 0.64 (0.55-0.75) | 0.33 (0.24-0.45) | 0.58 (0.46-0.73) | 0.71 (0.57-0.89) | 0.82 (0.65-1.04) | 0.60 (0.49-0.72) | 0.64 (0.50-0.82) | 0.78 (0.61-0.99) |
| Overweight BMI (vs normal/underweight) | 1.22 (1.00-1.48) | 0.93 (0.65-1.33) | 0.92 (0.70-1.20) | 1.35 (1.04-1.76) | 1.28 (0.97-1.68) | 1.11 (0.88-1.40) | 1.27 (0.95-1.70) | 1.53 (1.16-2.01) |
| Obese BMI (vs normal/underweight) | 1.65 (1.37-2.00) | 1.58 (1.13-2.20) | 1.27 (0.96-1.67) | 1.72 (1.31-2.26) | 1.34 (1.00-1.80) | 1.43 (1.15-1.79) | 1.39 (1.02-1.90) | 1.52 (1.12-2.05) |
| Relapse/subsequent malignancy (yes vs no) | 1.24 (1.03-1.49) | 1.43 (1.04-1.96) | 1.34 (1.03-1.75) | 1.26 (0.97-1.64) | 1.04 (0.78-1.39) | 1.25 (1.00-1.55) | 0.99 (0.72-1.36) | 0.78 (0.57-1.08) |
| Anthracycline (yes vs no) | 0.86 (0.67-1.11) | 0.76 (0.48-1.19) | 0.69 (0.46-1.03) | 0.53 (0.35-0.78) | 0.69 (0.46-1.05) | 0.71 (0.52-0.97) | 0.86 (0.57-1.30) | 0.71 (0.48-1.06) |
| Bleomycin (yes vs no) | 0.99 (0.78-1.25) | 0.95 (0.60-1.50) | 0.98 (0.66-1.46) | 1.10 (0.75-1.61) | 0.97 (0.65-1.43) | 1.25 (0.93-1.67) | 1.28 (0.86-1.90) | 1.30 (0.90-1.86) |
| Corticosteroids (yes vs no) | 0.83 (0.67-1.03) | 1.04 (0.68-1.59) | 1.00 (0.72-1.39) | 0.87 (0.63-1.19) | 0.96 (0.68-1.34) | 0.96 (0.75-1.24) | 1.01 (0.73-1.42) | 1.23 (0.88-1.71) |
| Chest radiation (yes vs no) | 1.14 (0.91-1.41) | 1.12 (0.75-1.67) | 1.06 (0.78-1.46) | 0.81 (0.61-1.08) | 0.87 (0.65-1.16) | 1.05 (0.82-1.35) | 0.91 (0.66-1.25) | 1.11 (0.82-1.50) |
| Alkylating agent (yes vs no) | 1.30 (1.05-1.61) | 1.27 (0.83-1.94) | 1.16 (0.83-1.62) | 1.34 (0.97-1.86) | 1.01 (0.73-1.41) | 1.06 (0.83-1.37) | 1.09 (0.78-1.52) | 0.92 (0.67-1.27) |
| Characteristic . | Quality of life . | |||||||
|---|---|---|---|---|---|---|---|---|
| General health (n = 1423) RR (95% CI) . | Physical function (n = 1548) RR (95% CI) . | Physical role limitation (n = 1545) RR (95% CI) . | Pain (n = 1549) RR (95% CI) . | Emotional role limitation (n = 1539) RR (95% CI) . | Vitality (n = 1427) RR (95% CI) . | Social functioning (n = 1551) RR (95% CI) . | Mental health (n = 1426) RR (95% CI) . | |
| Female sex (vs male) | 1.22 (1.03-1.44) | 1.58 (1.16-2.13) | 1.12 (0.88-1.43) | 1.31 (1.04-1.66) | 1.38 (1.08-1.77) | 1.56 (1.27-1.93) | 1.57 (1.20-2.05) | 1.37 (1.06-1.75) |
| Other race (vs white) | 0.90 (0.65-1.24) | 1.28 (0.77-2.11) | 1.45 (0.99-2.12) | 0.86 (0.53-1.39) | 1.62 (1.11-2.36) | 1.12 (0.79-1.58) | 1.43 (0.96-2.12) | 1.40 (0.95-2.07) |
| Former smoker (vs never) | 1.08 (0.88-1.32) | 1.31 (0.93-1.83) | 1.18 (0.90-1.55) | 1.22 (0.93-1.61) | 1.64 (1.24-2.17) | 1.23 (0.98-1.55) | 1.31 (0.96-1.78) | 1.54 (1.15-2.06) |
| Current smoker (vs never) | 1.39 (1.12-1.73) | 1.49 (1.00-2.20) | 1.47 (1.07-2.03) | 2.01 (1.52-2.65) | 1.93 (1.42-2.63) | 1.43 (1.10-1.86) | 1.78 (1.28-2.47) | 2.40 (1.80-3.18) |
| Meet CDC exercise guidelines (yes vs no) | 0.64 (0.55-0.75) | 0.33 (0.24-0.45) | 0.58 (0.46-0.73) | 0.71 (0.57-0.89) | 0.82 (0.65-1.04) | 0.60 (0.49-0.72) | 0.64 (0.50-0.82) | 0.78 (0.61-0.99) |
| Overweight BMI (vs normal/underweight) | 1.22 (1.00-1.48) | 0.93 (0.65-1.33) | 0.92 (0.70-1.20) | 1.35 (1.04-1.76) | 1.28 (0.97-1.68) | 1.11 (0.88-1.40) | 1.27 (0.95-1.70) | 1.53 (1.16-2.01) |
| Obese BMI (vs normal/underweight) | 1.65 (1.37-2.00) | 1.58 (1.13-2.20) | 1.27 (0.96-1.67) | 1.72 (1.31-2.26) | 1.34 (1.00-1.80) | 1.43 (1.15-1.79) | 1.39 (1.02-1.90) | 1.52 (1.12-2.05) |
| Relapse/subsequent malignancy (yes vs no) | 1.24 (1.03-1.49) | 1.43 (1.04-1.96) | 1.34 (1.03-1.75) | 1.26 (0.97-1.64) | 1.04 (0.78-1.39) | 1.25 (1.00-1.55) | 0.99 (0.72-1.36) | 0.78 (0.57-1.08) |
| Anthracycline (yes vs no) | 0.86 (0.67-1.11) | 0.76 (0.48-1.19) | 0.69 (0.46-1.03) | 0.53 (0.35-0.78) | 0.69 (0.46-1.05) | 0.71 (0.52-0.97) | 0.86 (0.57-1.30) | 0.71 (0.48-1.06) |
| Bleomycin (yes vs no) | 0.99 (0.78-1.25) | 0.95 (0.60-1.50) | 0.98 (0.66-1.46) | 1.10 (0.75-1.61) | 0.97 (0.65-1.43) | 1.25 (0.93-1.67) | 1.28 (0.86-1.90) | 1.30 (0.90-1.86) |
| Corticosteroids (yes vs no) | 0.83 (0.67-1.03) | 1.04 (0.68-1.59) | 1.00 (0.72-1.39) | 0.87 (0.63-1.19) | 0.96 (0.68-1.34) | 0.96 (0.75-1.24) | 1.01 (0.73-1.42) | 1.23 (0.88-1.71) |
| Chest radiation (yes vs no) | 1.14 (0.91-1.41) | 1.12 (0.75-1.67) | 1.06 (0.78-1.46) | 0.81 (0.61-1.08) | 0.87 (0.65-1.16) | 1.05 (0.82-1.35) | 0.91 (0.66-1.25) | 1.11 (0.82-1.50) |
| Alkylating agent (yes vs no) | 1.30 (1.05-1.61) | 1.27 (0.83-1.94) | 1.16 (0.83-1.62) | 1.34 (0.97-1.86) | 1.01 (0.73-1.41) | 1.06 (0.83-1.37) | 1.09 (0.78-1.52) | 0.92 (0.67-1.27) |
Bold indicates statistical significance (P < .05). Models for each risk of impairment are mutually adjusted for the variables above in addition to age at diagnosis and time since diagnosis.
BMI, body mass index.