Ex vivo thrombin generation parameters for mice treated with platelet inhibitors
| Parameter . | Lag time (min) . | Time to peak (min) . | Velocity index (nM/min) . | Peak (nM) . | ETP (nM/min) . |
|---|---|---|---|---|---|
| Control (untreated littermates, n = 7) | 4.4 ± 1.2 | 9.5 ± 3.2 | 12.8 ± 9.4 | 48.6 ± 26.6 | 541.3 ± 187.5 |
| Platelet-poor plasma (n = 5) | 4.3 ± 1.6 | 13.3 ± 2.8 | 1.5 ± 1.1* | 12.1 ± 5.3* | 264.6 ± 95.0* |
| Vehicle (water) (n = 3) | 4.8 ± 0.6 | 9.1 ± 1.2 | 14.0 ± 10.5 | 52.5 ± 27.9 | 569.1 ± 123.8 |
| High DAPT (n = 3) | 5.3 ± 0.6 | 10.4 ± 2.0 | 8.0 ± 2.8 | 38.3 ± 6.8 | 390.9 ± 84.5 |
| Vehicle (dimethyl sulfoxide) (n = 6) | 5.2 ± 1.1 | 10.4 ± 3.0 | 10.9 ± 5.8 | 46.6 ± 15.2 | 708.4 ± 158.1 |
| Ibrutinib (n = 7) | 6.1 ± 1.7 | 12.3 ± 3.7 | 8.1 ± 5.2 | 39.5 ± 11.3 | 667.4 ± 189.9 |
| Parameter . | Lag time (min) . | Time to peak (min) . | Velocity index (nM/min) . | Peak (nM) . | ETP (nM/min) . |
|---|---|---|---|---|---|
| Control (untreated littermates, n = 7) | 4.4 ± 1.2 | 9.5 ± 3.2 | 12.8 ± 9.4 | 48.6 ± 26.6 | 541.3 ± 187.5 |
| Platelet-poor plasma (n = 5) | 4.3 ± 1.6 | 13.3 ± 2.8 | 1.5 ± 1.1* | 12.1 ± 5.3* | 264.6 ± 95.0* |
| Vehicle (water) (n = 3) | 4.8 ± 0.6 | 9.1 ± 1.2 | 14.0 ± 10.5 | 52.5 ± 27.9 | 569.1 ± 123.8 |
| High DAPT (n = 3) | 5.3 ± 0.6 | 10.4 ± 2.0 | 8.0 ± 2.8 | 38.3 ± 6.8 | 390.9 ± 84.5 |
| Vehicle (dimethyl sulfoxide) (n = 6) | 5.2 ± 1.1 | 10.4 ± 3.0 | 10.9 ± 5.8 | 46.6 ± 15.2 | 708.4 ± 158.1 |
| Ibrutinib (n = 7) | 6.1 ± 1.7 | 12.3 ± 3.7 | 8.1 ± 5.2 | 39.5 ± 11.3 | 667.4 ± 189.9 |
Values indicate mean ± standard deviation; comparisons are by unpaired t test within each group. ETP, endogenous thrombin potential.
P < .05 compared with appropriately matched control, indicated by groups in the table.