Clinical characteristics of 15 pediatric patients with AML with FLT3-ITD
| N . | Age, y . | Sex . | WBC, 109/L . | Blast, % . | FLT3-ITD AR . | Cluster . | Other genetic alterations . | PRDM16 expression . | Non-CR . | Relapse . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| G_AML_012 | 11.4 | F | 4.5 | 78.4 | 0.71 | A | WT1, KMT2A-PTD | High | + | − | Dead |
| G_AML_136 | 12.8 | M | 7.0 | 76.4 | 0.70 | A | WT1 | High | − | + | Dead |
| G_AML_153 | 7.4 | M | 168.1 | 92 | 0.84 | A | — | High | + | + | Dead |
| G_AML_188 | 10.8 | F | 380.5 | 88.6 | 0.60 | A | — | High | − | + | Dead |
| G_AML_222 | 11.2 | F | 210.3 | 81.1 | 0.48 | A | NUP98-NSD1, WT1 | High | + | − | Dead |
| G_AML_225 | 17.3 | M | 147.9 | 85 | 0.73 | A | NUP98-NSD1, WT1 | High | + | + | Dead |
| G_AML_306 | 10.8 | F | 45.3 | 85.5 | 0.64 | A | KMT2A-PTD | High | + | + | Alive |
| G_AML_381 | 11.8 | M | 70.8 | 87.2 | 4.47 | A | KMT2A-PTD | High | + | + | Dead |
| G_AML_051 | 11.5 | F | 4.5 | 66.5 | 0.30 | B | NPM1 | High | − | − | Alive |
| G_AML_105 | 17.5 | F | 65.3 | 89 | 0.63 | B | — | Low | − | − | Alive |
| G_AML_319 | 2.8 | M | 17.7 | 95.1 | 0.77 | B | NPM1 | Low | − | − | Alive |
| G_AML_329 | 10.6 | F | 4.6 | 44.8 | 0.24 | B | — | High | − | − | Alive |
| G_AML_432 | 2.1 | F | 209.0 | 51.6 | 0.38 | B | NPM1 | Low | − | + | Alive |
| G_AML_437 | 16.9 | M | 8.5 | 23.1 | 0.11 | B | NPM1 | High | − | − | Alive |
| G_AML_018 | 2.7 | M | 114.4 | 79 | 0.34 | C | — | Low | − | − | Alive |
| N . | Age, y . | Sex . | WBC, 109/L . | Blast, % . | FLT3-ITD AR . | Cluster . | Other genetic alterations . | PRDM16 expression . | Non-CR . | Relapse . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| G_AML_012 | 11.4 | F | 4.5 | 78.4 | 0.71 | A | WT1, KMT2A-PTD | High | + | − | Dead |
| G_AML_136 | 12.8 | M | 7.0 | 76.4 | 0.70 | A | WT1 | High | − | + | Dead |
| G_AML_153 | 7.4 | M | 168.1 | 92 | 0.84 | A | — | High | + | + | Dead |
| G_AML_188 | 10.8 | F | 380.5 | 88.6 | 0.60 | A | — | High | − | + | Dead |
| G_AML_222 | 11.2 | F | 210.3 | 81.1 | 0.48 | A | NUP98-NSD1, WT1 | High | + | − | Dead |
| G_AML_225 | 17.3 | M | 147.9 | 85 | 0.73 | A | NUP98-NSD1, WT1 | High | + | + | Dead |
| G_AML_306 | 10.8 | F | 45.3 | 85.5 | 0.64 | A | KMT2A-PTD | High | + | + | Alive |
| G_AML_381 | 11.8 | M | 70.8 | 87.2 | 4.47 | A | KMT2A-PTD | High | + | + | Dead |
| G_AML_051 | 11.5 | F | 4.5 | 66.5 | 0.30 | B | NPM1 | High | − | − | Alive |
| G_AML_105 | 17.5 | F | 65.3 | 89 | 0.63 | B | — | Low | − | − | Alive |
| G_AML_319 | 2.8 | M | 17.7 | 95.1 | 0.77 | B | NPM1 | Low | − | − | Alive |
| G_AML_329 | 10.6 | F | 4.6 | 44.8 | 0.24 | B | — | High | − | − | Alive |
| G_AML_432 | 2.1 | F | 209.0 | 51.6 | 0.38 | B | NPM1 | Low | − | + | Alive |
| G_AML_437 | 16.9 | M | 8.5 | 23.1 | 0.11 | B | NPM1 | High | − | − | Alive |
| G_AML_018 | 2.7 | M | 114.4 | 79 | 0.34 | C | — | Low | − | − | Alive |
AR, allele ratio; CR, complete remission; F, female; M, male; PTD, partial tandem duplication; WBC, white blood cell.