Coagulation parameters of mice treated with FVIII, FIX, or HAPC1573
| . | PROC+/+;F8−/− with FVIII (2 U per mouse) . | PROC+/+;F8−/− with 1573 (20 µg per mouse) . | PROC+/+;F9−/− with FIX (2 U per mouse) . | PROC+/+;F9−/− with 1573 (20 µg per mouse) . |
|---|---|---|---|---|
| aPTT (s) | 23.0 ± 2.7*** | 30.6 ± 6.1* | 29.8 ± 4.6* | 34.1 ± 7.8ns |
| PT (s) | 14.1 ± 5.5 | 13.3 ± 9.2 | 12.8 ± 1.9 | 13.5 ± 3.1 |
| Fib (mg/dL) | 101.6 ± 7.5 | 105.1 ± 6.3 | 98.4 ± 11.5 | 103.7 ± 9.7 |
| Plt (number × 108/mL) | 9.0 ± 1.5 | 8.7 ± 2.1 | 7.5 ± 2.1 | 7.8 ± 2.7 |
| . | PROC+/+;F8−/− with FVIII (2 U per mouse) . | PROC+/+;F8−/− with 1573 (20 µg per mouse) . | PROC+/+;F9−/− with FIX (2 U per mouse) . | PROC+/+;F9−/− with 1573 (20 µg per mouse) . |
|---|---|---|---|---|
| aPTT (s) | 23.0 ± 2.7*** | 30.6 ± 6.1* | 29.8 ± 4.6* | 34.1 ± 7.8ns |
| PT (s) | 14.1 ± 5.5 | 13.3 ± 9.2 | 12.8 ± 1.9 | 13.5 ± 3.1 |
| Fib (mg/dL) | 101.6 ± 7.5 | 105.1 ± 6.3 | 98.4 ± 11.5 | 103.7 ± 9.7 |
| Plt (number × 108/mL) | 9.0 ± 1.5 | 8.7 ± 2.1 | 7.5 ± 2.1 | 7.8 ± 2.7 |
Data are represent as mean ± SD. n = 6 mice per group. Statistical significance was determined between untreated (values in Table 1) and corresponding treated groups (values in Table 2). ***P < .001; *P < .05 (1-way ANOVA).
Fib, fibrinogen measurement; ns, not significant; Plt, platelet count.