Three-year all-cause mortality and mortality from MCL based on age and year of diagnosis
| . | 3-y all-cause mortality . | 3-y mortality from MCL . | ||
|---|---|---|---|---|
| % . | Adjusted HR (95% CI) . | % . | Adjusted sub-HR (95% CI) . | |
| Overall | 39.8 | 27.3 | ||
| <60, pre-BTKi era | 20.5 | 1.00 | 17.3 | 1.00 |
| <60, BTKi era | 21.0 | 1.04 (0.82-1.31) | 14.3 | 0.80 (0.62-1.04) |
| 60-69, pre-BTKi era | 32.3 | 1.00 | 24.0 | 1.00 |
| 60-69, BTKi era | 28.4 | 0.85 (0.72-1.00) | 19.5 | 0.78 (0.64-0.94) |
| 70-79, pre-BTKi era | 47.8 | 1.00 | 33.9 | 1.00 |
| 70-79, BTKi era | 40.4 | 0.80 (0.70-0.92) | 27.5 | 0.76 (0.65-0.90) |
| ≥80, pre-BTKi era | 69.9 | 1.00 | 46.5 | 1.00 |
| ≥80, BTKi era | 65.8 | 0.91 (0.80-1.04) | 42.2 | 0.87 (0.75-1.02) |
| . | 3-y all-cause mortality . | 3-y mortality from MCL . | ||
|---|---|---|---|---|
| % . | Adjusted HR (95% CI) . | % . | Adjusted sub-HR (95% CI) . | |
| Overall | 39.8 | 27.3 | ||
| <60, pre-BTKi era | 20.5 | 1.00 | 17.3 | 1.00 |
| <60, BTKi era | 21.0 | 1.04 (0.82-1.31) | 14.3 | 0.80 (0.62-1.04) |
| 60-69, pre-BTKi era | 32.3 | 1.00 | 24.0 | 1.00 |
| 60-69, BTKi era | 28.4 | 0.85 (0.72-1.00) | 19.5 | 0.78 (0.64-0.94) |
| 70-79, pre-BTKi era | 47.8 | 1.00 | 33.9 | 1.00 |
| 70-79, BTKi era | 40.4 | 0.80 (0.70-0.92) | 27.5 | 0.76 (0.65-0.90) |
| ≥80, pre-BTKi era | 69.9 | 1.00 | 46.5 | 1.00 |
| ≥80, BTKi era | 65.8 | 0.91 (0.80-1.04) | 42.2 | 0.87 (0.75-1.02) |
Pre-BTKi era is defined as the year of diagnosis between 2007 and 2011; BTKi era is defined as the year of diagnosis between 2014 and 2018.
All the above analysis was adjusted for age, sex, race, stage, and median household income at the census level.
HRs or sub-HRs that are statistically significant (P < .05) are in bold.