Table 4.

Association between clinical and laboratory markers in hospitalized patients with COVID-19

Laboratory markerClinical outcomes
Length of hospital stayLength of ICU stayExtent of lung CT changes
Neutrophil/lymphocyte ratio    
 rs 0.065 0.174 0.384 
 P .752 .377 .044 
Platelet count    
 rs 0.030 −0.028 0.172 
 P .880 .884 .364 
CRP    
 rs 0.401 0.389 0.533 
 P .038 .037 .003* 
Lactate    
 rs 0.173 −0.030 −0.088 
 P .378 .874 .644 
Troponin    
 rs 0.148 0.279 0.309 
 P .452 .135 .096 
D-dimer    
 rs 0.348 0.436 0.511 
 P .06 .016 .004 
Fibrinogen    
 rs 0.173 −0.124 0.296* 
 P .418 .545 .142 
PT    
 rs 0.138 0.197 0.442 
 P .512 .324 .021 
aPTT    
 rs 0.158 0.126 0.292* 
 P .452 .531 .140 
FVIII activity    
 rs −0.235 −0.161 −0.096* 
 P .258 .423 .632 
FIX activity    
 rs 0.045 0.054 0.129* 
 P .812 .776 .496 
FXI activity    
 rs −0.106 −0.298 −0.226* 
 P .629 .148 .278 
FXII activity    
 rs −0.066 −0.236 −0.219 
 P .753 .236 .272 
VWF:Ag    
 rs −0.174 −0.008 −0.135 
 P .439 .971 .528 
Ristocetin cofactor activity    
 rs 0.086 −0.053 0.136 
 P .684 .793 .498 
P-selectin    
 rs 0.335 0.396 0.559 
 P .081 .030 .001 
AT    
 rs 0.098 0.065 0.213* 
 P .612 .738 .112 
uPAR    
 rs 0.177 0.231 0.072 
 P .366 .220 .707 
PAI-1    
 rs 0.383 0.586 0.488 
 P .044 .001 .006 
PAP    
 rs 0.274 0.603 0.332 
 P .166 .001 .078 
FXIIa:C1 esterase    
 rs −0.006 0.175 0.012* 
 P .977 .372 .952 
Kallikrein:C1 esterase    
 rs 0.174 −0.060 −0.185* 
 P .396 .760 .345 
FXIa:C1 esterase    
 rs −0.009 −0.009 0.176* 
 P .657 .647 .369 
FXIa:α1-antitrypsin    
 rs 0.053 −0.132 −0.014 
 P .798 .512 .488 
FXIa:AT    
 rs 0.142 0.385 0.385 
 P .488 .043 .043 
FIXa:AT    
 rs 0.461 0.588 0.497 
 P .018 .002 .007 
MVTF    
 rs 0.26 0.33 0.37 
 P .17 .082 .047 
Laboratory markerClinical outcomes
Length of hospital stayLength of ICU stayExtent of lung CT changes
Neutrophil/lymphocyte ratio    
 rs 0.065 0.174 0.384 
 P .752 .377 .044 
Platelet count    
 rs 0.030 −0.028 0.172 
 P .880 .884 .364 
CRP    
 rs 0.401 0.389 0.533 
 P .038 .037 .003* 
Lactate    
 rs 0.173 −0.030 −0.088 
 P .378 .874 .644 
Troponin    
 rs 0.148 0.279 0.309 
 P .452 .135 .096 
D-dimer    
 rs 0.348 0.436 0.511 
 P .06 .016 .004 
Fibrinogen    
 rs 0.173 −0.124 0.296* 
 P .418 .545 .142 
PT    
 rs 0.138 0.197 0.442 
 P .512 .324 .021 
aPTT    
 rs 0.158 0.126 0.292* 
 P .452 .531 .140 
FVIII activity    
 rs −0.235 −0.161 −0.096* 
 P .258 .423 .632 
FIX activity    
 rs 0.045 0.054 0.129* 
 P .812 .776 .496 
FXI activity    
 rs −0.106 −0.298 −0.226* 
 P .629 .148 .278 
FXII activity    
 rs −0.066 −0.236 −0.219 
 P .753 .236 .272 
VWF:Ag    
 rs −0.174 −0.008 −0.135 
 P .439 .971 .528 
Ristocetin cofactor activity    
 rs 0.086 −0.053 0.136 
 P .684 .793 .498 
P-selectin    
 rs 0.335 0.396 0.559 
 P .081 .030 .001 
AT    
 rs 0.098 0.065 0.213* 
 P .612 .738 .112 
uPAR    
 rs 0.177 0.231 0.072 
 P .366 .220 .707 
PAI-1    
 rs 0.383 0.586 0.488 
 P .044 .001 .006 
PAP    
 rs 0.274 0.603 0.332 
 P .166 .001 .078 
FXIIa:C1 esterase    
 rs −0.006 0.175 0.012* 
 P .977 .372 .952 
Kallikrein:C1 esterase    
 rs 0.174 −0.060 −0.185* 
 P .396 .760 .345 
FXIa:C1 esterase    
 rs −0.009 −0.009 0.176* 
 P .657 .647 .369 
FXIa:α1-antitrypsin    
 rs 0.053 −0.132 −0.014 
 P .798 .512 .488 
FXIa:AT    
 rs 0.142 0.385 0.385 
 P .488 .043 .043 
FIXa:AT    
 rs 0.461 0.588 0.497 
 P .018 .002 .007 
MVTF    
 rs 0.26 0.33 0.37 
 P .17 .082 .047 

Spearman correlation coefficient is given unless otherwise indicated (Spearman or Pearson was used according to variable distribution but yielded similar results).

aPTT, activated partial thromboplastin time; ICU, intensive care unit; PAP, plasmin-antiplasmin complexes; uPAR, urokinase-type plasminogen activator receptor; VWF, von Willebrand factor.

*

Pearson correlation coefficient.

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