Clinical characteristics of CDX2/UBTF B-ALL
| . | . | . | . | . | . | . | . | Immunophenotype . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample ID . | Sample status . | Gender . | Age group . | Outcome . | Relapse . | MRD >1% at EOI . | Karyotype . | CD10 . | IgM . | CD19 . | CD20 . | CD22 . | CD34 . |
| ADU_0788_ 201543 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | G-banding: failure. | Dim | NA | Posi | Posi | Posi | Posi |
| ADI_0252 | Diagnosis | Female | Adult | Dead | Yes | NA | 46,XX,t(1;7)(q25;p12),add (6)(q13),der(11)add(11)(p?13) add(11)(q?22), del(13) (q12q22),?add(18)(q23)[23] | Neg | NA | Posi | Neg | Posi | Posi |
| MLL_13382 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | 46,XX[20] | Neg | NA | Posi | Neg | Neg | Posi |
| MLL_137117 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | 46,XX[20] | Neg | NA | Posi | Neg | Dim | Posi |
| SJALL060150 | Diagnosis | Female | Adult | Alive (Refractory post cycle 2 of Induction) | Yes | NA | NA | Neg | Posi | Posi | Neg | Dim | Posi |
| AYAII_0107 | Diagnosis | Female | AYA | Alive (CR1) | No | NA | NA | Posi | NA | Posi | Neg | Neg | Posi |
| AYAII_0369 | Diagnosis | Female | AYA | Alive (CR1) | No | Positive | Hyperdiploid. 82-86 (near tetraploid) gain of 1q in 7/20 | Neg | NA | Posi | NA | NA | Posi |
| MLL_13360 | Diagnosis | Female | AYA | Dead (CR1; hepatorenal syndrome with acute renal failure, sepsis) | No | NA | 46,XX[15] | Neg | NA | Posi | Neg | Dim | Posi |
| MLL_202248- M228 | Diagnosis | Female | AYA | Alive (CR1) | No | NA | 46,XX[22] | Neg | NA | Posi | Neg | Dim | Posi |
| SJALL054476 | Diagnosis | Male | AYA | Alive | Yes | NA | 46,XY,t(12;13)(p11.2;q14)[30]/ 46,idem,del(6)(q21q25)[7]/ 46,XY[14];abnormal;del(6q) | Neg | Posi | Posi | Neg | Posi | Posi |
| SJALL054518 | Diagnosis | Male | AYA | NA | NA | NA | Inv(9)(p13q13) | Neg | Posi | Posi | Neg | Dim | Posi |
| SJALL066367 | Diagnosis | Male | AYA | Alive (CR1) | Yes | NA | NA | Dim | Neg | Weak | Neg | Posi | Posi |
| SJBALL016287 | Diagnosis | Female | AYA | Alive (CR1) | No | Positive | 46,XX[20] | Neg | Posi | NA | NA | NA | NA |
| SJBALL020165 | Diagnosis | Female | AYA | NA | No | Positive | 46,XX,del(9)(q13q22) [9]/46,XX[11] | Neg | Posi | Posi | Neg | Posi | Posi |
| SJBALL020169 | Diagnosis | Female | AYA | NA | No | Positive | 46,XX,del(9)(q13q22) [6]/46,XX[14] | Neg | Posi | Posi | Neg | NA | Posi |
| SJBALL020889 | Diagnosis | Female | Childhood HR | Alive (CR1) | No | Positive | 46,XX,del(9)(q12q32) [10]/92,idemx2,+ add(1)(p11),-20[8]/46,XX[20] | Neg | Posi | NA | NA | NA | NA |
| SJBALL022051 | Diagnosis | Male | Childhood HR | Alive (CR1) | No | NA | 46,XY,der(6)t(1;6)(q21.1;p25.3), add(14)(q32.3)[13]/46,XY[7] | Dim | Posi | Posi | Dim | Posi | NA |
| SJALL058818_R1 | Relapse | Male | Adult | Dead | Yes | Positive | Complex, near tetraploidy | Neg | Posi | Posi | NA | Posi | Posi |
| SJALL073397_R1 | Relapse | Female | Adult | Refractory after INO | Yes | Positive | NA | Neg | NA | Posi | NA | Posi | Posi |
| SJBALL042249_R1 | Relapse | Female | Adult | Dead (refractory disease) | Yes | Positive | 46,XX,dup(1)(q21q42),der (?2)t(2;13)(p11.2;q14), -3,add(6)(p23),?inv (7)(p13p22),der(?8)t (8;13)(q22;q22), del(9) (q13q22),add(12) (q24.3),add(13)(q14),del (13)(q12),del(?15)(q15q24), add(20)(q13.1),+mar | Dim | NA | Posi | Neg | Neg | Posi |
| SJALL073380_R1 | Relapse | Female | AYA | Alive (CR2) | Yes | NA | NA | Neg | NA | Posi | NA | Posi | Posi |
| SJALL073389_R1 | Relapse | Female | AYA | Alive (CR2) | Yes | NA | NA | Neg | NA | Posi | NA | Dim | Posi |
| . | . | . | . | . | . | . | . | Immunophenotype . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample ID . | Sample status . | Gender . | Age group . | Outcome . | Relapse . | MRD >1% at EOI . | Karyotype . | CD10 . | IgM . | CD19 . | CD20 . | CD22 . | CD34 . |
| ADU_0788_ 201543 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | G-banding: failure. | Dim | NA | Posi | Posi | Posi | Posi |
| ADI_0252 | Diagnosis | Female | Adult | Dead | Yes | NA | 46,XX,t(1;7)(q25;p12),add (6)(q13),der(11)add(11)(p?13) add(11)(q?22), del(13) (q12q22),?add(18)(q23)[23] | Neg | NA | Posi | Neg | Posi | Posi |
| MLL_13382 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | 46,XX[20] | Neg | NA | Posi | Neg | Neg | Posi |
| MLL_137117 | Diagnosis | Female | Adult | Alive (CR1) | No | NA | 46,XX[20] | Neg | NA | Posi | Neg | Dim | Posi |
| SJALL060150 | Diagnosis | Female | Adult | Alive (Refractory post cycle 2 of Induction) | Yes | NA | NA | Neg | Posi | Posi | Neg | Dim | Posi |
| AYAII_0107 | Diagnosis | Female | AYA | Alive (CR1) | No | NA | NA | Posi | NA | Posi | Neg | Neg | Posi |
| AYAII_0369 | Diagnosis | Female | AYA | Alive (CR1) | No | Positive | Hyperdiploid. 82-86 (near tetraploid) gain of 1q in 7/20 | Neg | NA | Posi | NA | NA | Posi |
| MLL_13360 | Diagnosis | Female | AYA | Dead (CR1; hepatorenal syndrome with acute renal failure, sepsis) | No | NA | 46,XX[15] | Neg | NA | Posi | Neg | Dim | Posi |
| MLL_202248- M228 | Diagnosis | Female | AYA | Alive (CR1) | No | NA | 46,XX[22] | Neg | NA | Posi | Neg | Dim | Posi |
| SJALL054476 | Diagnosis | Male | AYA | Alive | Yes | NA | 46,XY,t(12;13)(p11.2;q14)[30]/ 46,idem,del(6)(q21q25)[7]/ 46,XY[14];abnormal;del(6q) | Neg | Posi | Posi | Neg | Posi | Posi |
| SJALL054518 | Diagnosis | Male | AYA | NA | NA | NA | Inv(9)(p13q13) | Neg | Posi | Posi | Neg | Dim | Posi |
| SJALL066367 | Diagnosis | Male | AYA | Alive (CR1) | Yes | NA | NA | Dim | Neg | Weak | Neg | Posi | Posi |
| SJBALL016287 | Diagnosis | Female | AYA | Alive (CR1) | No | Positive | 46,XX[20] | Neg | Posi | NA | NA | NA | NA |
| SJBALL020165 | Diagnosis | Female | AYA | NA | No | Positive | 46,XX,del(9)(q13q22) [9]/46,XX[11] | Neg | Posi | Posi | Neg | Posi | Posi |
| SJBALL020169 | Diagnosis | Female | AYA | NA | No | Positive | 46,XX,del(9)(q13q22) [6]/46,XX[14] | Neg | Posi | Posi | Neg | NA | Posi |
| SJBALL020889 | Diagnosis | Female | Childhood HR | Alive (CR1) | No | Positive | 46,XX,del(9)(q12q32) [10]/92,idemx2,+ add(1)(p11),-20[8]/46,XX[20] | Neg | Posi | NA | NA | NA | NA |
| SJBALL022051 | Diagnosis | Male | Childhood HR | Alive (CR1) | No | NA | 46,XY,der(6)t(1;6)(q21.1;p25.3), add(14)(q32.3)[13]/46,XY[7] | Dim | Posi | Posi | Dim | Posi | NA |
| SJALL058818_R1 | Relapse | Male | Adult | Dead | Yes | Positive | Complex, near tetraploidy | Neg | Posi | Posi | NA | Posi | Posi |
| SJALL073397_R1 | Relapse | Female | Adult | Refractory after INO | Yes | Positive | NA | Neg | NA | Posi | NA | Posi | Posi |
| SJBALL042249_R1 | Relapse | Female | Adult | Dead (refractory disease) | Yes | Positive | 46,XX,dup(1)(q21q42),der (?2)t(2;13)(p11.2;q14), -3,add(6)(p23),?inv (7)(p13p22),der(?8)t (8;13)(q22;q22), del(9) (q13q22),add(12) (q24.3),add(13)(q14),del (13)(q12),del(?15)(q15q24), add(20)(q13.1),+mar | Dim | NA | Posi | Neg | Neg | Posi |
| SJALL073380_R1 | Relapse | Female | AYA | Alive (CR2) | Yes | NA | NA | Neg | NA | Posi | NA | Posi | Posi |
| SJALL073389_R1 | Relapse | Female | AYA | Alive (CR2) | Yes | NA | NA | Neg | NA | Posi | NA | Dim | Posi |
CR, complete remission; EOI, end of induction; HR, high-risk; NA, not available; Neg, negative; Posi, positive.