Table 1.

Age, sex, and MGUS characteristics by 3 risk groups and Olmsted County reference population

EAAAFDROlmsted County
Full sample N = 1223 N = 327 N = 1093 N = 21 463 
Age (mean, SD) 64.4 (8.9) 64.5 (9.5) 65.2 (10.5) 64.9 (10.5) 
Sex (% Male) 532 (43.5%) 137 (41.9%) 474 (43.4%) 9469 (44.1%) 
MGUS prevalence (%, CI) 10.8% (8.8, 12.7) 16.5% (12.2, 20.8) 18.3% (15.8, 20.8) 3.0% (2.8, 3.2) 
MGUS characteristics* N = 127 N = 58 N = 215 N = 694 
M-protein size (g/dL)     
 Negligible (<0.2) 94 (80.3%) 41 (74.5%) 161 (81.3%) 55 (9.4%) 
 0.2-1.5 22 (18.8%) 13 (23.6%) 32 (16.2%) 411 (70.4%) 
 ≥1.5 1 (0.9%) 0 (0%) 5 (2.5%) 118 (20.2%) 
 Not done 12 82 
Isotype     
 IgG 83 (65.4%) 32 (55.2%) 120 (55.8%) 474 (68.5%) 
 IgA 19 (15.0%) 17 (29.3%) 31 (14.4%) 75 (10.8%) 
 IgM 16 (12.6%) 6 (10.3%) 47 (21.9%) 117 (16.9%) 
 Biclonal 9 (7.1%) 3 (5.2%) 17 (7.9%) 26 (3.8%) 
 Missing 
EAAAFDROlmsted County
Full sample N = 1223 N = 327 N = 1093 N = 21 463 
Age (mean, SD) 64.4 (8.9) 64.5 (9.5) 65.2 (10.5) 64.9 (10.5) 
Sex (% Male) 532 (43.5%) 137 (41.9%) 474 (43.4%) 9469 (44.1%) 
MGUS prevalence (%, CI) 10.8% (8.8, 12.7) 16.5% (12.2, 20.8) 18.3% (15.8, 20.8) 3.0% (2.8, 3.2) 
MGUS characteristics* N = 127 N = 58 N = 215 N = 694 
M-protein size (g/dL)     
 Negligible (<0.2) 94 (80.3%) 41 (74.5%) 161 (81.3%) 55 (9.4%) 
 0.2-1.5 22 (18.8%) 13 (23.6%) 32 (16.2%) 411 (70.4%) 
 ≥1.5 1 (0.9%) 0 (0%) 5 (2.5%) 118 (20.2%) 
 Not done 12 82 
Isotype     
 IgG 83 (65.4%) 32 (55.2%) 120 (55.8%) 474 (68.5%) 
 IgA 19 (15.0%) 17 (29.3%) 31 (14.4%) 75 (10.8%) 
 IgM 16 (12.6%) 6 (10.3%) 47 (21.9%) 117 (16.9%) 
 Biclonal 9 (7.1%) 3 (5.2%) 17 (7.9%) 26 (3.8%) 
 Missing 
*

MGUS for AA, EA, and FDR assessed using MALDI (MASS-FIX). MGUS for Olmsted County assessed using SPEP followed by immunofixation.

Excludes biclonal MGUS.

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