Most frequent AEs related to Nivo+ICE (NICE) (n = 9)
| AEs . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | All . | Percentage . |
|---|---|---|---|---|---|---|
| Nausea | 6 | 1 | 0 | 0 | 7 | 78 |
| Anemia | 4 | 2 | 0 | 0 | 6 | 67 |
| Alanine aminotransferase increased | 5 | 0 | 0 | 0 | 5 | 56 |
| Fatigue | 5 | 0 | 0 | 0 | 5 | 56 |
| Vomiting | 5 | 0 | 0 | 0 | 5 | 56 |
| Alkaline phosphatase increased | 4 | 0 | 0 | 0 | 4 | 44 |
| Aspartate aminotransferase increased | 4 | 0 | 0 | 0 | 4 | 44 |
| Hypertension | 2 | 2 | 0 | 0 | 4 | 44 |
| Hyponatremia | 4 | 0 | 0 | 0 | 4 | 44 |
| Hypophosphatemia | 0 | 2 | 2 | 0 | 4 | 44 |
| Neutrophil count decreased | 1 | 1 | 0 | 2 | 4 | 44 |
| Abdominal pain | 3 | 0 | 0 | 0 | 3 | 33 |
| Anxiety | 3 | 0 | 0 | 0 | 3 | 33 |
| Constipation | 2 | 1 | 0 | 0 | 3 | 33 |
| Creatinine increased | 2 | 1 | 0 | 0 | 3 | 33 |
| Hypoalbuminemia | 3 | 0 | 0 | 0 | 3 | 33 |
| Hypokalemia | 3 | 0 | 0 | 0 | 3 | 33 |
| Platelet count decreased | 0 | 3 | 0 | 0 | 3 | 33 |
| Edema limbs | 2 | 0 | 0 | 0 | 2 | 22 |
| Hiccups | 1 | 1 | 0 | 0 | 2 | 22 |
| Hyperglycemia | 1 | 1 | 0 | 0 | 2 | 22 |
| Rash maculopapular | 2 | 0 | 0 | 0 | 2 | 22 |
| Sinus tachycardia | 2 | 0 | 0 | 0 | 2 | 22 |
| White blood cell decreased | 0 | 1 | 1 | 0 | 2 | 22 |
| AEs . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | All . | Percentage . |
|---|---|---|---|---|---|---|
| Nausea | 6 | 1 | 0 | 0 | 7 | 78 |
| Anemia | 4 | 2 | 0 | 0 | 6 | 67 |
| Alanine aminotransferase increased | 5 | 0 | 0 | 0 | 5 | 56 |
| Fatigue | 5 | 0 | 0 | 0 | 5 | 56 |
| Vomiting | 5 | 0 | 0 | 0 | 5 | 56 |
| Alkaline phosphatase increased | 4 | 0 | 0 | 0 | 4 | 44 |
| Aspartate aminotransferase increased | 4 | 0 | 0 | 0 | 4 | 44 |
| Hypertension | 2 | 2 | 0 | 0 | 4 | 44 |
| Hyponatremia | 4 | 0 | 0 | 0 | 4 | 44 |
| Hypophosphatemia | 0 | 2 | 2 | 0 | 4 | 44 |
| Neutrophil count decreased | 1 | 1 | 0 | 2 | 4 | 44 |
| Abdominal pain | 3 | 0 | 0 | 0 | 3 | 33 |
| Anxiety | 3 | 0 | 0 | 0 | 3 | 33 |
| Constipation | 2 | 1 | 0 | 0 | 3 | 33 |
| Creatinine increased | 2 | 1 | 0 | 0 | 3 | 33 |
| Hypoalbuminemia | 3 | 0 | 0 | 0 | 3 | 33 |
| Hypokalemia | 3 | 0 | 0 | 0 | 3 | 33 |
| Platelet count decreased | 0 | 3 | 0 | 0 | 3 | 33 |
| Edema limbs | 2 | 0 | 0 | 0 | 2 | 22 |
| Hiccups | 1 | 1 | 0 | 0 | 2 | 22 |
| Hyperglycemia | 1 | 1 | 0 | 0 | 2 | 22 |
| Rash maculopapular | 2 | 0 | 0 | 0 | 2 | 22 |
| Sinus tachycardia | 2 | 0 | 0 | 0 | 2 | 22 |
| White blood cell decreased | 0 | 1 | 1 | 0 | 2 | 22 |