Toxicities possibly, probably, or definitely related to metformin
| Toxicity type . | Worst grade . | Total . | Percentage* . | |
|---|---|---|---|---|
| 1 . | 2 . | |||
| Diarrhea | 11 | 1 | 12 | 27.9 |
| Nausea | 6 | 1 | 7 | 16.3 |
| Abdominal pain, intermittent | 4 | 0 | 4 | 9.3 |
| Increased alanine aminotransferase (ALT) | 2 | 1 | 3 | 7 |
| Increased aspartate aminotransferase (AST) | 2 | 1 | 3 | 7 |
| Fatigue | 2 | 0 | 2 | 4.7 |
| Headache | 2 | 0 | 2 | 4.7 |
| Papulopustular rash, localized | 2 | 0 | 2 | 4.7 |
| Anorexia, intermittent | 1 | 0 | 1 | 2.3 |
| Anxiety, intermittent | 1 | 0 | 1 | 2.3 |
| Dyspepsia | 1 | 0 | 1 | 2.3 |
| Eye disorders, other-pruritis | 1 | 0 | 1 | 2.3 |
| Eye disorders, other-redness/edema | 1 | 0 | 1 | 2.3 |
| Hyperkalemia | 1 | 0 | 1 | 2.3 |
| Vomiting, intermittent | 1 | 0 | 1 | 2.3 |
| Watering eyes | 1 | 0 | 1 | 2.3 |
| Worst grade across all toxicities (no. of patients) | 9 | 4 | 13 | |
| Toxicity type . | Worst grade . | Total . | Percentage* . | |
|---|---|---|---|---|
| 1 . | 2 . | |||
| Diarrhea | 11 | 1 | 12 | 27.9 |
| Nausea | 6 | 1 | 7 | 16.3 |
| Abdominal pain, intermittent | 4 | 0 | 4 | 9.3 |
| Increased alanine aminotransferase (ALT) | 2 | 1 | 3 | 7 |
| Increased aspartate aminotransferase (AST) | 2 | 1 | 3 | 7 |
| Fatigue | 2 | 0 | 2 | 4.7 |
| Headache | 2 | 0 | 2 | 4.7 |
| Papulopustular rash, localized | 2 | 0 | 2 | 4.7 |
| Anorexia, intermittent | 1 | 0 | 1 | 2.3 |
| Anxiety, intermittent | 1 | 0 | 1 | 2.3 |
| Dyspepsia | 1 | 0 | 1 | 2.3 |
| Eye disorders, other-pruritis | 1 | 0 | 1 | 2.3 |
| Eye disorders, other-redness/edema | 1 | 0 | 1 | 2.3 |
| Hyperkalemia | 1 | 0 | 1 | 2.3 |
| Vomiting, intermittent | 1 | 0 | 1 | 2.3 |
| Watering eyes | 1 | 0 | 1 | 2.3 |
| Worst grade across all toxicities (no. of patients) | 9 | 4 | 13 | |
Percentage of total toxicities.