Table 1.

Overview of current and alternative platelet products

ProductDonorsCollectionModificationsStorageStorage duration(Planned) indicationBacterial growth riskVolume (mL)PreparationSummary
RT-stored platelets (standard of care) Regular donor restrictions Apheresis/phlebotomy Pathogen reduction, leukoreduction, irradiation, additive solutions, volume reduction Liquid 20° to 24°C 5-7 d Prophylactic/therapeutic (current standard of care) High (∼1:1000-3000)141  200-250 N/A Pro: Best in vivo recovery and survival
Con: Short shelf life, bacterial growth, low in vitro quality 
CSPs Regular donor restrictions Apheresis/phlebotomy Additive solutions, leukoreduction Liquid 1° to 6°C 3 d, 14 d* Therapeutic Low143,144 200-250 N/A Pro: Extended shelf life, preserved in vitro quality
Con: reduced in vivo recovery and survival, in vivo hemostatic function uncertain? 
Cold-stored whole blood Group O, low titer anti-A/B, possibly males only Phlebotomy Leukoreduction Liquid 1°C to 6°C 21 d (CPD), 35 d (CPDA-1) Therapeutic (especially outside of hospital, trauma) Low142  500 N/A Pro: Extended shelf life, includes all blood components
Con: Possible ABO, Rh mismatch, lower recovery and survival, lower platelet dose, in vivo platelet function uncertain 
CPPs Regular donor restrictions Apheresis/phlebotomy Leukoreduction, resuspension in saline or plasma Solid/frozen, −80°C 3 y (≥5 y reported) Therapeutic Perceived to be very low16  20-50 Thawing and resuspension Pro: Extended shelf life (years), almost normal in vivo survival, most in vivo performance data
Con: logistics (freezer, thawing, preparation) 
Freeze-dried (lyophilized) platelets Group O Apheresis Leukoreduction Solid/powder, RT 3 y Therapeutic (especially outside of hospital, military) Perceived to be very low (including pathogen reduction and culture)134  30-50 Reconstitution in sterile water Pro: Extended shelf life (years), logistics
Con: reduced in vitro function, in vivo hemostatic function uncertain 
ProductDonorsCollectionModificationsStorageStorage duration(Planned) indicationBacterial growth riskVolume (mL)PreparationSummary
RT-stored platelets (standard of care) Regular donor restrictions Apheresis/phlebotomy Pathogen reduction, leukoreduction, irradiation, additive solutions, volume reduction Liquid 20° to 24°C 5-7 d Prophylactic/therapeutic (current standard of care) High (∼1:1000-3000)141  200-250 N/A Pro: Best in vivo recovery and survival
Con: Short shelf life, bacterial growth, low in vitro quality 
CSPs Regular donor restrictions Apheresis/phlebotomy Additive solutions, leukoreduction Liquid 1° to 6°C 3 d, 14 d* Therapeutic Low143,144 200-250 N/A Pro: Extended shelf life, preserved in vitro quality
Con: reduced in vivo recovery and survival, in vivo hemostatic function uncertain? 
Cold-stored whole blood Group O, low titer anti-A/B, possibly males only Phlebotomy Leukoreduction Liquid 1°C to 6°C 21 d (CPD), 35 d (CPDA-1) Therapeutic (especially outside of hospital, trauma) Low142  500 N/A Pro: Extended shelf life, includes all blood components
Con: Possible ABO, Rh mismatch, lower recovery and survival, lower platelet dose, in vivo platelet function uncertain 
CPPs Regular donor restrictions Apheresis/phlebotomy Leukoreduction, resuspension in saline or plasma Solid/frozen, −80°C 3 y (≥5 y reported) Therapeutic Perceived to be very low16  20-50 Thawing and resuspension Pro: Extended shelf life (years), almost normal in vivo survival, most in vivo performance data
Con: logistics (freezer, thawing, preparation) 
Freeze-dried (lyophilized) platelets Group O Apheresis Leukoreduction Solid/powder, RT 3 y Therapeutic (especially outside of hospital, military) Perceived to be very low (including pathogen reduction and culture)134  30-50 Reconstitution in sterile water Pro: Extended shelf life (years), logistics
Con: reduced in vitro function, in vivo hemostatic function uncertain 
*

Variance for military and civilian blood centers.

Depending on preparation.

Thrombosomes.

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