SCI definitions
| SCI feature . | SCI definition . | SCI assigned score . |
|---|---|---|
| Composite cardiac disease/dysfunction | Coronary artery disease, congestive heart failure, history of myocardial infarction, or left ventricular ejection fraction ≤ 50% OR atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias OR valvular heart disease (except mitral valve prolapse) | 1 |
| Moderate pulmonary dysfunction | DLCo* or FEV1 66-80% or dyspnea on slight activity | 1 |
| Age ≥ 60 y | 1 | |
| Severe pulmonary dysfunction | DLCo* or FEV1 < 66 or dyspnea at rest/oxygen dependent | 2 |
| Moderate to severe hepatic dysfunction | Serum bilirubin > 1.5 times ULN; ALT or AST > 2.5 times ULN, or chronic hepatitis | 2 |
| Mild renal dysfunction | eGFR† between 60 and 89.9 mL/min per 1.73 m2 | 2 |
| Moderate to severe renal dysfunction | eGFR < 60 mL/min per 1.73 m2 | 3 |
| SCI feature . | SCI definition . | SCI assigned score . |
|---|---|---|
| Composite cardiac disease/dysfunction | Coronary artery disease, congestive heart failure, history of myocardial infarction, or left ventricular ejection fraction ≤ 50% OR atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias OR valvular heart disease (except mitral valve prolapse) | 1 |
| Moderate pulmonary dysfunction | DLCo* or FEV1 66-80% or dyspnea on slight activity | 1 |
| Age ≥ 60 y | 1 | |
| Severe pulmonary dysfunction | DLCo* or FEV1 < 66 or dyspnea at rest/oxygen dependent | 2 |
| Moderate to severe hepatic dysfunction | Serum bilirubin > 1.5 times ULN; ALT or AST > 2.5 times ULN, or chronic hepatitis | 2 |
| Mild renal dysfunction | eGFR† between 60 and 89.9 mL/min per 1.73 m2 | 2 |
| Moderate to severe renal dysfunction | eGFR < 60 mL/min per 1.73 m2 | 3 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; DLCo, diffusion capacity of the lung for CO; FEV1, forced expiratory volume in 1 second; ULN, upper limit of normal.
DLCo was corrected for hemoglobin using the formula of Cotes et al.49
eGFR was calculated using the CKD-EPI equation of Levey et al.34