Multivariable HRs for NRM and OS
| . | NRM . | OS . | |||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| SCI score | |||||
| 0 | Reference | ||||
| 1 | 2.04 (1.11-3.74) | .021 | 1.71 (1.13-2.59) | .0105 | |
| 2 | 3.09 (1.66-5.73) | .000 | 2.6 (1.7-3.97) | <.001 | |
| 3 | 5.03 (2.64-9.6) | .000 | 3.15 (1.95-5.07) | <.001 | |
| ≥ 4 | 7.04 (3.61-13.73) | .000 | 4.08 (2.46-6.77) | 0 | |
| Regimen | |||||
| Melphalan-based | Reference | ||||
| TBI-based | 0.89 (0.53-1.5) | .670 | 1.03 (0.71-1.49) | .888 | |
| Karnofsky performance status | |||||
| ≤ 80 | Reference | ||||
| 90 − 100 | 1.53 (1.08-2.17) | .017 | 1.53 (1.17-2) | .002 | |
| CIBMTR disease risk | |||||
| Low/Intermediate | Reference | ||||
| High | 1.05 (0.7-1.58) | .818 | 1.31 (0.97-1.76) | .078 | |
| Unclassifiable | 0.57 (0.27-1.18) | .130 | 0.53 (0.28-0.98) | .042 | |
| Recipient CMV serostatus | |||||
| Negative | Reference | ||||
| Positive | 1.13 (0.8-1.61) | .491 | 1.19 (0.91-1.57) | .197 | |
| Donor type | |||||
| Matched related | Reference | ||||
| Matched unrelated | 1.1 (0.73-1.65) | .662 | 0.92 (0.68-1.24) | .590 | |
| Mismatched | 2.4 (1.51-3.82) | .000 | 1.7 (1.19-2.42) | .003 | |
| . | NRM . | OS . | |||
|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | ||
| SCI score | |||||
| 0 | Reference | ||||
| 1 | 2.04 (1.11-3.74) | .021 | 1.71 (1.13-2.59) | .0105 | |
| 2 | 3.09 (1.66-5.73) | .000 | 2.6 (1.7-3.97) | <.001 | |
| 3 | 5.03 (2.64-9.6) | .000 | 3.15 (1.95-5.07) | <.001 | |
| ≥ 4 | 7.04 (3.61-13.73) | .000 | 4.08 (2.46-6.77) | 0 | |
| Regimen | |||||
| Melphalan-based | Reference | ||||
| TBI-based | 0.89 (0.53-1.5) | .670 | 1.03 (0.71-1.49) | .888 | |
| Karnofsky performance status | |||||
| ≤ 80 | Reference | ||||
| 90 − 100 | 1.53 (1.08-2.17) | .017 | 1.53 (1.17-2) | .002 | |
| CIBMTR disease risk | |||||
| Low/Intermediate | Reference | ||||
| High | 1.05 (0.7-1.58) | .818 | 1.31 (0.97-1.76) | .078 | |
| Unclassifiable | 0.57 (0.27-1.18) | .130 | 0.53 (0.28-0.98) | .042 | |
| Recipient CMV serostatus | |||||
| Negative | Reference | ||||
| Positive | 1.13 (0.8-1.61) | .491 | 1.19 (0.91-1.57) | .197 | |
| Donor type | |||||
| Matched related | Reference | ||||
| Matched unrelated | 1.1 (0.73-1.65) | .662 | 0.92 (0.68-1.24) | .590 | |
| Mismatched | 2.4 (1.51-3.82) | .000 | 1.7 (1.19-2.42) | .003 | |
CIBMTR, Center for International Blood and Marrow Transplant Research; CMV, cytomegalovirus.