Models’ NRM discrimination by the AUC (95% CI)
| . | SCI . | HCT-CI . | Comorbidity-Age[40]* Index . | Comorbidity-Age[6o]* Index . |
|---|---|---|---|---|
| MSKCC cohort | ||||
| Years | ||||
| 1 | 70.3 (64.4-76.1) | 61.7 (54.6-67.1) | 61.0 (54.0-68.1) | 58.8 (55.1-67.0) |
| 2 | 68.9 (63.3-74.4) | 63.1 (55.8-67.2) | 62.5 (55.8-69.2) | 59.4 (56.9-68.1) |
| 3 | 68.7 (63.1-74.4) | 63.0 (55.6-66.9) | 62.7 (55. 8-69.6) | 59.6 (56.9-68.5) |
| 4 | 67.5 (61.6-73.5) | 63.3 (56.0-67.4) | 62.5 (55.4-69.7) | 59.9 (56.5-68.6) |
| Sheba cohort | ||||
| Years | ||||
| 1 | 72.0 (62.0-76.5) | 65.7 (56.7-74.6) | 63.7 (55.2-72.2) | 64.4 (56.0-72.8) |
| 2 | 67.6 (57.4-77.9) | 62.8 (53.3-72.2) | 61.1 (52.0-70.3) | 57.1 (52.4-70.6) |
| 3 | 64.9 (54.1-75.7) | 63.6 (53.1-74.1) | 63.5 (53.0-74.1) | 62.4 (51.9-73.0) |
| 4 | 61.8 (48.0-75.5) | 64.4 (52.7-76.1) | 61.9 (49.8-74.0) | 59.2 (46.6-71.8) |
| . | SCI . | HCT-CI . | Comorbidity-Age[40]* Index . | Comorbidity-Age[6o]* Index . |
|---|---|---|---|---|
| MSKCC cohort | ||||
| Years | ||||
| 1 | 70.3 (64.4-76.1) | 61.7 (54.6-67.1) | 61.0 (54.0-68.1) | 58.8 (55.1-67.0) |
| 2 | 68.9 (63.3-74.4) | 63.1 (55.8-67.2) | 62.5 (55.8-69.2) | 59.4 (56.9-68.1) |
| 3 | 68.7 (63.1-74.4) | 63.0 (55.6-66.9) | 62.7 (55. 8-69.6) | 59.6 (56.9-68.5) |
| 4 | 67.5 (61.6-73.5) | 63.3 (56.0-67.4) | 62.5 (55.4-69.7) | 59.9 (56.5-68.6) |
| Sheba cohort | ||||
| Years | ||||
| 1 | 72.0 (62.0-76.5) | 65.7 (56.7-74.6) | 63.7 (55.2-72.2) | 64.4 (56.0-72.8) |
| 2 | 67.6 (57.4-77.9) | 62.8 (53.3-72.2) | 61.1 (52.0-70.3) | 57.1 (52.4-70.6) |
| 3 | 64.9 (54.1-75.7) | 63.6 (53.1-74.1) | 63.5 (53.0-74.1) | 62.4 (51.9-73.0) |
| 4 | 61.8 (48.0-75.5) | 64.4 (52.7-76.1) | 61.9 (49.8-74.0) | 59.2 (46.6-71.8) |
The Comorbidity-Age Index was developed with age ≥ 40 years as a threshold to add a point to the HCT-CI. Because the impact of age has likely changed over time, we tested the index with the original age threshold (Comorbidity-Age[40] Index) and with age ≥ 60 years as a threshold (Comorbidity-Age[60] Index).