Toxicities by dose level per Bearman scale21
| . | Grade . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DL1 (1200 cGy;n = 3) . | DL2 (1400 cGy;n = 6) . | DL3 (1600 cGy;n = 3) . | DL4 (1800 cGy;n = 7) . | DL5 (2000 cGy;n = 12) . | |||||||
| Organ assessed . | 1 . | 2 . | 1 . | 2 . | 1 . | 2 . | 1 . | 2 . | 3 . | 1 . | 2 . |
| Bladder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiac | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
| CNS | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| GI | 1 | 1 | 1 | 0 | 0 | 2 | 3 | 0 | 0 | 7 | 2 |
| Hepatic | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 0 |
| Pulmonary | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1* | 0 | 0 |
| Renal | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Stomatitis | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 8 | 1 |
| . | Grade . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DL1 (1200 cGy;n = 3) . | DL2 (1400 cGy;n = 6) . | DL3 (1600 cGy;n = 3) . | DL4 (1800 cGy;n = 7) . | DL5 (2000 cGy;n = 12) . | |||||||
| Organ assessed . | 1 . | 2 . | 1 . | 2 . | 1 . | 2 . | 1 . | 2 . | 3 . | 1 . | 2 . |
| Bladder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiac | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
| CNS | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| GI | 1 | 1 | 1 | 0 | 0 | 2 | 3 | 0 | 0 | 7 | 2 |
| Hepatic | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 0 |
| Pulmonary | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1* | 0 | 0 |
| Renal | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Stomatitis | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 8 | 1 |
Dose-limiting toxicity.