Demographic and laboratory characteristics of discovery and replication cohorts included in genome-wide association study
| Characteristic . | Discovery cohort . | Replication cohort . |
|---|---|---|
| Total (n) | 4927 | 834 |
| Age, y (mean [SD]) | 66.65 (13.64) | 68.39 (12.55) |
| Female (%) | 1952 (39.8) | 294 (35.5) |
| OD, mean (SD) | 0.78 (0.77) | 1.05 (1.00) |
| Functional assay (positive %) | 1426 (29.6) | 195 (23.4) |
| Characteristic . | Discovery cohort . | Replication cohort . |
|---|---|---|
| Total (n) | 4927 | 834 |
| Age, y (mean [SD]) | 66.65 (13.64) | 68.39 (12.55) |
| Female (%) | 1952 (39.8) | 294 (35.5) |
| OD, mean (SD) | 0.78 (0.77) | 1.05 (1.00) |
| Functional assay (positive %) | 1426 (29.6) | 195 (23.4) |
Anti-PF4/heparin antibody OD values were determined using ELISA in both discovery and replication cohorts. Functional assays (positive %) are results of the heparin-induced platelet activation assay (discovery cohort) or serotonin release assay (replication cohort).