Crude and adjusted association between baseline factor levels and the (spontaneous) joint bleeding rate
| . | Crude estimate . | Crude HR (95% CI) . | P . | Adjusted estimate* . | Adjusted HR (95% CI)* . | P . |
|---|---|---|---|---|---|---|
| Joint bleeding rate | ||||||
| Baseline FVIII/IX levels | −0.058 | 0.94 (0.93-0.96) | <.001 | −0.056 | 0.94 (0.92-0.97) | <.001 |
| Spontaneous joint bleeding rate | ||||||
| Baseline FVIII/IX levels | −0.122 | 0.88 (0.83-0.94) | <.001 | −0.126 | 0.88 (0.82-0.95) | <.001 |
| . | Crude estimate . | Crude HR (95% CI) . | P . | Adjusted estimate* . | Adjusted HR (95% CI)* . | P . |
|---|---|---|---|---|---|---|
| Joint bleeding rate | ||||||
| Baseline FVIII/IX levels | −0.058 | 0.94 (0.93-0.96) | <.001 | −0.056 | 0.94 (0.92-0.97) | <.001 |
| Spontaneous joint bleeding rate | ||||||
| Baseline FVIII/IX levels | −0.122 | 0.88 (0.83-0.94) | <.001 | −0.126 | 0.88 (0.82-0.95) | <.001 |
Adjusted for hemophilia type and VWF activity levels. VWF activity levels were imputed for 132 of 286 participants.