Predictors for 30-Day Mortality of ICH in Adult Patients with ITP in the Training Cohort
| Variables . | Univariate . | Multivariate . | |||||
|---|---|---|---|---|---|---|---|
| . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | β . |
| Age ≥70, yr | 2.586 | (0.923-7.244) | .071 | 1.122 | (0.145-8.683) | .912 | — |
| Sex | 0.957 | (0.414-2.210) | .917 | — | — | — | — |
| Platelet count at ITP diagnosis ≤10 × 109/L | 2.057 | (0.895-4.727) | .089 | 2.903 | (0.427-19.762) | .276 | 2.586 |
| Platelet count at ICH ≤10 × 109/L | 7.778 | (2.490-24.290) | <.001* | 7.993 | (1.052-60.733) | .045* | 2.079 |
| Hypertension | 1.192 | (0.390-3.644) | .758 | — | — | — | — |
| Diabetes mellitus | 0.592 | (0.175-2.005) | .400 | — | — | — | — |
| Previous infections | 0.726 | (0.177-2.986) | .657 | — | — | — | — |
| Anticoagulants and antiplatelet agents | 0.559 | (0.107-2.912) | .489 | — | — | — | — |
| NSAIDs | 0.421 | (0.045-3.907) | .447 | — | — | — | — |
| Combination of serious infections | 6.286 | (1.842-21.452) | .003* | 5.940 | (0.791-44.587) | .083 | 1.782 |
| Preceding head trauma or surgery | 0.071 | (0.003-1.421) | .084 | 0.531 | (0.022-12.872) | .697 | |
| No treatment received | 1.218 | (0.486-3.055) | .674 | — | — | — | — |
| Glucocorticoid resistance | 1.248 | (0.534-2.918) | .609 | — | — | — | — |
| Preceding bleeding grade | |||||||
| Mild | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| Moderate | 2.479 | (0.716-8.583) | .152 | 3.967 | (0.358-43.947) | .261 | 1.378 |
| Severe | 8.185 | (2.848-23.523) | <.001* | 17.757 | (1.790-176.180) | .014* | 2.877 |
| Bleeding event in the last month | 1.443 | (0.652-3.191) | .366 | — | — | — | — |
| Type of ICH | |||||||
| IPH | 19.161 | (4.213-87.141) | <.001* | 37.029 | (4.529-302.773) | .001* | 3.612 |
| SAH | 0.224 | (0.061-0.823) | .024* | 0.844 | (0.120-5.940) | .865 | — |
| SDH | 0.418 | (0.128-1.371) | .150 | — | — | — | — |
| GCS on admission | |||||||
| 15 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| 13-14 | 5.051 | (1.661-15.359) | .004* | 2.928 | (0.445-19.249) | .264 | 1.074 |
| 9-12 | 11.111 | (3.313-37.260) | <.001* | 17.294 | (1.687-177.256) | .016* | 2.851 |
| ≤8 | 44.444 | (4.941-399.773) | .001* | 81.894 | (4.195-1598.624) | .004* | 4.406 |
| Variables . | Univariate . | Multivariate . | |||||
|---|---|---|---|---|---|---|---|
| . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | β . |
| Age ≥70, yr | 2.586 | (0.923-7.244) | .071 | 1.122 | (0.145-8.683) | .912 | — |
| Sex | 0.957 | (0.414-2.210) | .917 | — | — | — | — |
| Platelet count at ITP diagnosis ≤10 × 109/L | 2.057 | (0.895-4.727) | .089 | 2.903 | (0.427-19.762) | .276 | 2.586 |
| Platelet count at ICH ≤10 × 109/L | 7.778 | (2.490-24.290) | <.001* | 7.993 | (1.052-60.733) | .045* | 2.079 |
| Hypertension | 1.192 | (0.390-3.644) | .758 | — | — | — | — |
| Diabetes mellitus | 0.592 | (0.175-2.005) | .400 | — | — | — | — |
| Previous infections | 0.726 | (0.177-2.986) | .657 | — | — | — | — |
| Anticoagulants and antiplatelet agents | 0.559 | (0.107-2.912) | .489 | — | — | — | — |
| NSAIDs | 0.421 | (0.045-3.907) | .447 | — | — | — | — |
| Combination of serious infections | 6.286 | (1.842-21.452) | .003* | 5.940 | (0.791-44.587) | .083 | 1.782 |
| Preceding head trauma or surgery | 0.071 | (0.003-1.421) | .084 | 0.531 | (0.022-12.872) | .697 | |
| No treatment received | 1.218 | (0.486-3.055) | .674 | — | — | — | — |
| Glucocorticoid resistance | 1.248 | (0.534-2.918) | .609 | — | — | — | — |
| Preceding bleeding grade | |||||||
| Mild | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| Moderate | 2.479 | (0.716-8.583) | .152 | 3.967 | (0.358-43.947) | .261 | 1.378 |
| Severe | 8.185 | (2.848-23.523) | <.001* | 17.757 | (1.790-176.180) | .014* | 2.877 |
| Bleeding event in the last month | 1.443 | (0.652-3.191) | .366 | — | — | — | — |
| Type of ICH | |||||||
| IPH | 19.161 | (4.213-87.141) | <.001* | 37.029 | (4.529-302.773) | .001* | 3.612 |
| SAH | 0.224 | (0.061-0.823) | .024* | 0.844 | (0.120-5.940) | .865 | — |
| SDH | 0.418 | (0.128-1.371) | .150 | — | — | — | — |
| GCS on admission | |||||||
| 15 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| 13-14 | 5.051 | (1.661-15.359) | .004* | 2.928 | (0.445-19.249) | .264 | 1.074 |
| 9-12 | 11.111 | (3.313-37.260) | <.001* | 17.294 | (1.687-177.256) | .016* | 2.851 |
| ≤8 | 44.444 | (4.941-399.773) | .001* | 81.894 | (4.195-1598.624) | .004* | 4.406 |
GCS, Glasgow Coma Scale; NSAIDs, nonsteroidal antiinflammatory drugs; SDH, subdural hemorrhage.
P < 0.05.