Table 2. A summary of brain histology... | American Society of Hematology

Table 2.

A summary of brain histology findings in patients with TA-TMA

General CNS histology	Vascular histology attributable to TA-TMA	Location of TA-TMA–related changes
Global white matter loss Edema (global and perivascular) Macrophage infiltration Demyelination Hydrocephalus ex vacuo Gliosis	Increased vascular wall-to-lumen ratio Vascular basement membrane splitting Vascular wall reduplication Perivascular hemosiderin deposition Perivascular hemorrhage Microinfarcts Ischemic reperfusion injury and repair	Cerebellum Brainstem Cerebral white matter

General CNS histology	Vascular histology attributable to TA-TMA	Location of TA-TMA–related changes
Global white matter loss Edema (global and perivascular) Macrophage infiltration Demyelination Hydrocephalus ex vacuo Gliosis	Increased vascular wall-to-lumen ratio Vascular basement membrane splitting Vascular wall reduplication Perivascular hemosiderin deposition Perivascular hemorrhage Microinfarcts Ischemic reperfusion injury and repair	Cerebellum Brainstem Cerebral white matter

General and vascular-specific histologic findings are shown for patients with TA-TMA who underwent autopsy at our institution and had sufficient brain tissue available for examination (n =13). These findings coincide with the general and vascular injury scores shown for each patient in Table 1.

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