Table 3. A summary of brain imaging... | American Society of Hematology

Table 3.

A summary of brain imaging findings in patients with TA-TMA

General brain findings	Brain imaging findings attributable to TA-TMA	Location of TA-TMA–related changes
Volume loss (mild to severe) Progressive cerebral white matter signal Cerebellar and cortical signal Basal ganglia and thalamic signal Multifocal diffusion restriction	Gross hemorrhage Microhemorrhages PRES Siderosis	Cerebellum Brainstem Cerebral white matter Thalamus Cortex Choroid plexus

General brain findings	Brain imaging findings attributable to TA-TMA	Location of TA-TMA–related changes
Volume loss (mild to severe) Progressive cerebral white matter signal Cerebellar and cortical signal Basal ganglia and thalamic signal Multifocal diffusion restriction	Gross hemorrhage Microhemorrhages PRES Siderosis	Cerebellum Brainstem Cerebral white matter Thalamus Cortex Choroid plexus

Brain imaging findings are shown for patients with TA-TMA who underwent autopsy at our institution and had brain imaging obtained before and after TA-TMA diagnosis (n = 7) for comparison. These findings were categorized as “general” or “attributable to TA-TMA.” Parenchymal hemorrhages (gross or micro) in the cortex, deep gray matter, and/or corpus callosum were present in 6 patients. Regional diffusion restriction (n = 5) and PRES (n = 4) were also common findings. One patient had superficial siderosis and multifocal punctate parenchymal hemorrhages.

View Large

This Feature Is Available To Subscribers Only