Measures of performance to predict major bleeding
| Prediction model . | Sensitivity, % . | Specificity, % . | PPV, % . | NPV, % . | C-statistic . |
|---|---|---|---|---|---|
| Modified ACCP | 61.6 (52.6-70.6) | 66.2 (64.3-68.2) | 8.3 (6.4-10.2) | 97.2 (96.4-98.0) | 0.65 (0.60-0.69) |
| Modified RIETE | 1.7 (0.0-4.0) | 99.4 (99.1-99.7) | 12.5 (0.0-28.7) | 95.1 (94.5-96.2) | 0.51 (0.49-0.52) |
| Modified VTE-BLEED | 53.1 (43.9-62.3) | 70.9 (69.1-72.8) | 8.1 (6.1-10.1) | 96.9 (96.1-97.7) | 0.61 (0.56-0.66) |
| Modified HAS-BLEED | 20.2 (12.8-27.5) | 93.1 (92.0-94.1) | 12.6 (7.8-17.4) | 95.9 (95.1-96.8) | 0.57 (0.53-0.61) |
| Modified OBRI | 3.4 (0.1-6.7) | 98.5 (98.1-99.0) | 10.3 (0.7-19.8) | 95.4 (94.6-96.2) | 0.51 (0.49-0.51) |
| CHAP model* | 52.7 (43.4-61.9) | 76.1 (74.3-77.9) | 10.1 (7.6-12.5) | 96.9 (96.1-97.7) | 0.65 (0.60-0.70) |
| Prediction model . | Sensitivity, % . | Specificity, % . | PPV, % . | NPV, % . | C-statistic . |
|---|---|---|---|---|---|
| Modified ACCP | 61.6 (52.6-70.6) | 66.2 (64.3-68.2) | 8.3 (6.4-10.2) | 97.2 (96.4-98.0) | 0.65 (0.60-0.69) |
| Modified RIETE | 1.7 (0.0-4.0) | 99.4 (99.1-99.7) | 12.5 (0.0-28.7) | 95.1 (94.5-96.2) | 0.51 (0.49-0.52) |
| Modified VTE-BLEED | 53.1 (43.9-62.3) | 70.9 (69.1-72.8) | 8.1 (6.1-10.1) | 96.9 (96.1-97.7) | 0.61 (0.56-0.66) |
| Modified HAS-BLEED | 20.2 (12.8-27.5) | 93.1 (92.0-94.1) | 12.6 (7.8-17.4) | 95.9 (95.1-96.8) | 0.57 (0.53-0.61) |
| Modified OBRI | 3.4 (0.1-6.7) | 98.5 (98.1-99.0) | 10.3 (0.7-19.8) | 95.4 (94.6-96.2) | 0.51 (0.49-0.51) |
| CHAP model* | 52.7 (43.4-61.9) | 76.1 (74.3-77.9) | 10.1 (7.6-12.5) | 96.9 (96.1-97.7) | 0.65 (0.60-0.70) |
Values in parentheses are 95% CIs.
Calculated based on binary risk groups (high vs not high). High-risk and non–high-risk patients were defined as those with ≥2.5% and <2.5% predicted risk of major bleeding at 1 y, respectively, according to the CHAP model.