Findings that raise suspicion for ITP vs an IPD
| Characteristics . | ITP . | IPD . |
|---|---|---|
| Personal medical history | Sudden onset of new bruising, petechiae, or other bleeding symptoms Secondary ITP: other autoimmunity or immune cytopenias | Presenting at age <6 mo Longstanding history of easy bruising or other bleeding symptoms Bleeding disproportionate to severity of thrombocytopenia |
| Family history | Primary ITP: no relevant history Secondary ITP: family history of immune cytopenias, other autoimmunity, lymphoma | Family members with thrombocytopenia (AD or X-linked) |
| Laboratory findings | Isolated thrombocytopenia Moderately elevated MPV* and IPF | Normal platelet count† or persistent moderately low platelet count‡ Significantly elevated or markedly depressed MPV* or IPF |
| Physical examination findings | Primary ITP: skin and/or mucosal bleeding findings Secondary ITP: splenomegaly, lymphadenopathy | Syndromic features |
| Characteristics . | ITP . | IPD . |
|---|---|---|
| Personal medical history | Sudden onset of new bruising, petechiae, or other bleeding symptoms Secondary ITP: other autoimmunity or immune cytopenias | Presenting at age <6 mo Longstanding history of easy bruising or other bleeding symptoms Bleeding disproportionate to severity of thrombocytopenia |
| Family history | Primary ITP: no relevant history Secondary ITP: family history of immune cytopenias, other autoimmunity, lymphoma | Family members with thrombocytopenia (AD or X-linked) |
| Laboratory findings | Isolated thrombocytopenia Moderately elevated MPV* and IPF | Normal platelet count† or persistent moderately low platelet count‡ Significantly elevated or markedly depressed MPV* or IPF |
| Physical examination findings | Primary ITP: skin and/or mucosal bleeding findings Secondary ITP: splenomegaly, lymphadenopathy | Syndromic features |