Table 4.

Overall response rate stratified by novel SA vs CA in patients with R/R PTCL in phase I, II, and III clinical trials subdivided by histological subtype

Novel SACombination chemotherapyP value
PTCL-NOS 0.31 [0.27, 0.35] (n = 49)* 0.42 [0.28, 0.58] (n = 6) .16 
AITL 0.43 [0.36, 0.50] (n = 30) 0.22 [0.03, 0.70] (n = 2) .37 
ALCL 0.48 [0.36, 0.60] (n = 20) 0.34 [0.17, 0.57] (n = 2) .31 
NK/TCL 0.52 [0.42, 0.61] (n=9) 0.63 [0.34, 0.86] (n=1) .46 
Novel SACombination chemotherapyP value
PTCL-NOS 0.31 [0.27, 0.35] (n = 49)* 0.42 [0.28, 0.58] (n = 6) .16 
AITL 0.43 [0.36, 0.50] (n = 30) 0.22 [0.03, 0.70] (n = 2) .37 
ALCL 0.48 [0.36, 0.60] (n = 20) 0.34 [0.17, 0.57] (n = 2) .31 
NK/TCL 0.52 [0.42, 0.61] (n=9) 0.63 [0.34, 0.86] (n=1) .46 
*

Numbers in parenthesis represent number of clinical trials included for analysis in that category.

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