Recurrent neuropsychiatric symptoms stratified by history of stroke
| Neuropsychiatric symptoms* with associated questions . | All 26 patients† (%) . | 10 patients No stroke (%) . | 16 patients Stroke (%) . | P‡ . |
|---|---|---|---|---|
| Headaches Do you have regular headaches? | 23 (88) | 10 (100) | 13 (81) | .26 |
| Poor concentration Do you feel that you have poor concentration? For example, do you have difficulty focusing on a task or at work/school? | 17 (65) | 6 (60) | 11 (69) | .70 |
| Depression Have you ever had significant depression, now or in the past? | 16 (62) | 6 (60) | 10 (63) | 1.0 |
| Headache with aura (presumed migraine)§ Do you have any vision changes prior to your headaches? | 15 (58) | 7 (70) | 8 (50) | .43 |
| Vision changes Do you ever get blurry vision or changes in your vision? | 12 (46) | 4 (40) | 8 (50) | .70 |
| Forgetfulness Do you feel that you often forget things, or your memory is not as good as others around you? | 12 (46) | 3 (30) | 9 (56) | .25 |
| Fatigue Do you often feel very tired or like your whole body is weak? | 12 (46) | 4 (40) | 8 (50) | 1.0 |
| Neuropathy Do you ever feel numbness or tingling in your hands or feet? | 11 (42) | 2 (20) | 9 (56) | .11 |
| Dysarthria Do you ever have difficulty with speaking, such as slurring of your speech? | 10 (38) | 1 (10) | 9 (56) | .04 |
| Loss of vision Do you ever have loss of vision? | 7 (27) | 3 (30) | 4 (25) | 1.0 |
| Seizure Have you ever had a seizure? | 6 (23) | 2 (20) | 4 (40) | 1.0 |
| Transient weakness Do you ever have sudden weakness in 1 part of the body, such as an arm or leg? | 5 (19) | 1 (10) | 4 (25) | .39 |
| Falls Have you fallen frequently? | 5 (19) | 1 (10) | 4 (25) | .62 |
| Dysphagia Do you ever have difficulty swallowing? | 3 (12) | 0 | 3 (19) | .26 |
| No symptoms‖ | 1 (4) | 0 | 1 (6) | NA |
| Neuropsychiatric symptoms* with associated questions . | All 26 patients† (%) . | 10 patients No stroke (%) . | 16 patients Stroke (%) . | P‡ . |
|---|---|---|---|---|
| Headaches Do you have regular headaches? | 23 (88) | 10 (100) | 13 (81) | .26 |
| Poor concentration Do you feel that you have poor concentration? For example, do you have difficulty focusing on a task or at work/school? | 17 (65) | 6 (60) | 11 (69) | .70 |
| Depression Have you ever had significant depression, now or in the past? | 16 (62) | 6 (60) | 10 (63) | 1.0 |
| Headache with aura (presumed migraine)§ Do you have any vision changes prior to your headaches? | 15 (58) | 7 (70) | 8 (50) | .43 |
| Vision changes Do you ever get blurry vision or changes in your vision? | 12 (46) | 4 (40) | 8 (50) | .70 |
| Forgetfulness Do you feel that you often forget things, or your memory is not as good as others around you? | 12 (46) | 3 (30) | 9 (56) | .25 |
| Fatigue Do you often feel very tired or like your whole body is weak? | 12 (46) | 4 (40) | 8 (50) | 1.0 |
| Neuropathy Do you ever feel numbness or tingling in your hands or feet? | 11 (42) | 2 (20) | 9 (56) | .11 |
| Dysarthria Do you ever have difficulty with speaking, such as slurring of your speech? | 10 (38) | 1 (10) | 9 (56) | .04 |
| Loss of vision Do you ever have loss of vision? | 7 (27) | 3 (30) | 4 (25) | 1.0 |
| Seizure Have you ever had a seizure? | 6 (23) | 2 (20) | 4 (40) | 1.0 |
| Transient weakness Do you ever have sudden weakness in 1 part of the body, such as an arm or leg? | 5 (19) | 1 (10) | 4 (25) | .39 |
| Falls Have you fallen frequently? | 5 (19) | 1 (10) | 4 (25) | .62 |
| Dysphagia Do you ever have difficulty swallowing? | 3 (12) | 0 | 3 (19) | .26 |
| No symptoms‖ | 1 (4) | 0 | 1 (6) | NA |
NA, not applicable.
These neuropsychiatric symptoms were chosen based on the interviews with hTTP patients. All questions were followed up with: “How often? When did it start? Please describe.”
The 20-mo-old patient is not included in the table because these symptoms did not apply to him. His parents were only asked about seizures, which he did not have. He appears to have normal development.
χ2 analysis or Fisher’s exact test (if there were <5 subjects per category) was performed to assess the difference in frequency of symptoms in patients with or without stroke.
Patients were asked about auras as a follow-up question if they answered yes to having headaches. The auras were described as “sparkly eyes,” “flashes of lights,” “wavy lines,” or transient vision loss.
The asymptomatic patient is a 12-y-old girl who was diagnosed at birth after having cardiac arrest and stroke as a newborn. She currently reports no symptoms since the start of the plasma-derived factor VIII concentrate (pdFVIII) for prophylaxis.