Occurrence and resolution of LT cytopenias
| . | Anemia . | Thrombocytopenia . | Lymphocytopenia . | Neutropenia . |
|---|---|---|---|---|
| All patients (N = 115), n (%) | ||||
| Cytopenias resolved to grade ≤2 by 90 days | 49 (43) | 43 (37) | 44 (38) | 43 (37) |
| LT cytopenias | 3 (3) | 9 (8) | 8 (7) | 9 (8) |
| Responders (n = 60) | ||||
| Cytopenias resolved to grade ≤2 by 90 days | 45 (75) | 39 (65) | 40 (67) | 38 (63) |
| LT cytopenias | 2 (3) | 8 (13) | 7 (12) | 9 (15) |
| Probability of grade 3 to 4 cytopenias not resolved to grade ≤2, % (95% CI) | ||||
| Month 3 | 100 | 100 | 83 (27.3-97.5) | 100 |
| Month 6 | 0 | 50 (15.2-77.5) | 42 (5.6-76.7) | 44 (13.6-71.9) |
| Month 9 | 0 | 25 (3.7-55.8) | 42 (5.6-76.7) | 22 (3.4-51.3) |
| Month 12 | 0 | NE | 21 (0.9-59.5) | NE |
| . | Anemia . | Thrombocytopenia . | Lymphocytopenia . | Neutropenia . |
|---|---|---|---|---|
| All patients (N = 115), n (%) | ||||
| Cytopenias resolved to grade ≤2 by 90 days | 49 (43) | 43 (37) | 44 (38) | 43 (37) |
| LT cytopenias | 3 (3) | 9 (8) | 8 (7) | 9 (8) |
| Responders (n = 60) | ||||
| Cytopenias resolved to grade ≤2 by 90 days | 45 (75) | 39 (65) | 40 (67) | 38 (63) |
| LT cytopenias | 2 (3) | 8 (13) | 7 (12) | 9 (15) |
| Probability of grade 3 to 4 cytopenias not resolved to grade ≤2, % (95% CI) | ||||
| Month 3 | 100 | 100 | 83 (27.3-97.5) | 100 |
| Month 6 | 0 | 50 (15.2-77.5) | 42 (5.6-76.7) | 44 (13.6-71.9) |
| Month 9 | 0 | 25 (3.7-55.8) | 42 (5.6-76.7) | 22 (3.4-51.3) |
| Month 12 | 0 | NE | 21 (0.9-59.5) | NE |
LT cytopenias were defined as grade ≥3 occurring at or persisting beyond 90 days after infusion.
NE, not estimable.