Baseline assessment and monitoring for patients with SMM
Test . | At baseline . | How often do we repeat it . |
---|---|---|
CBC | Yes | 3-6 mo |
Vitamin B12, TSH, folic acid, iron, transferrin, and ferritin | Yes | When hemoglobin decreases |
Creatinine | Yes | 3-6 mo |
Calcium | Yes | 3-6 mo |
Alkaline phosphatase | Yes | 12 mo |
24-h urinary protein | Yes | 12 mo |
NT-proBNP and troponin | Yes | 12 mo |
SPEP and IEP | Yes | 3-6 mo |
sFLC | Yes | 3-6 mo |
Skeletal imaging | PET-CT (if unavailable, we recommend TBLDCT and MRI of spine and pelvis) | TBLDCT every 6-12 mo if monoclonal protein is rising |
BM biopsy and aspirate and FISH | Yes | When progression is suspected |
Test . | At baseline . | How often do we repeat it . |
---|---|---|
CBC | Yes | 3-6 mo |
Vitamin B12, TSH, folic acid, iron, transferrin, and ferritin | Yes | When hemoglobin decreases |
Creatinine | Yes | 3-6 mo |
Calcium | Yes | 3-6 mo |
Alkaline phosphatase | Yes | 12 mo |
24-h urinary protein | Yes | 12 mo |
NT-proBNP and troponin | Yes | 12 mo |
SPEP and IEP | Yes | 3-6 mo |
sFLC | Yes | 3-6 mo |
Skeletal imaging | PET-CT (if unavailable, we recommend TBLDCT and MRI of spine and pelvis) | TBLDCT every 6-12 mo if monoclonal protein is rising |
BM biopsy and aspirate and FISH | Yes | When progression is suspected |
CBC, complete blood count; IEP, immunofixation; NT-proBNP, N-terminal probrain natriuretic peptide; SPEP, serum protein electrophoresis; TBLDCT, total-body low-dose CT scan; TSH, thyroid-stimulating hormone.