Evaluation of CMV infections in seropositive recipients of HCT from donors in the bank of CMVpp65CTLs
| HLA restriction of immunodominant CMVpp65CTL from HCT donor . | N . | CMV reactivation . | Level Of CMV reactivation . | Disease . | Failed therapy . | |||
|---|---|---|---|---|---|---|---|---|
| Yes . | No . | No . | Low (2-13/slide; <10 000) . | High >100 >10 000 . | ||||
| B0702 | 25 | 19 (75%) | 6 | 6 | 10 | 9 | 3 (15%) | 2 (8%) |
| A 0201 DOM | 28 | 21 (75%) | 7 | 7 | 16 | 5 | 2 (9%) | 1 (3.5%) |
| A 1101 DOM | 1 | 1 (100%) | 0 | 0 | 1 | 0 | 0 (0%) | 0 (0%) |
| A 0101 DOM | 4 | 4 (100%) | 0 | 0 | 2 | 2 | 0 (0%) | 0 (0%) |
| A 2402 DOM | 4 | 4 (100%) | 0 | 0 | 2 | 2 | 0 (0%) | 0 (0%) |
| A 2601 DOM | 4 | 2 (50%) | 2 | 2 | 1 | 1 | 1 (25%) | 1 (25%) |
| B 0801 DOM | 3 | 3 (100%) | 0 | 0 | 1 | 2 | 0 (0%) | 0 (0%) |
| B 40, 42, 44 DOM HERN Specific | 9 | 6 (66%) | 3 | 3 | 2 | 4 | 2 (24%) | 1 (11%) |
| B 35 DOM | 8 | 7 (87.5%) | 1 | 1 | 3 | 4 | 3 (37.5%) | 3 (37.5%) *P = .048 |
| Other HLA A,B,C alleles DOM | 13 | 11 (84%) | 2 | 2 | 4 | 7 | 2 (15%) | 0 (0%) |
| HLA DR alleles DOM | 14 | 13 (92%) | 1 | 1 | 4 | 9 | 7 (50%) | 5 (35%) |
| HLA restriction of immunodominant CMVpp65CTL from HCT donor . | N . | CMV reactivation . | Level Of CMV reactivation . | Disease . | Failed therapy . | |||
|---|---|---|---|---|---|---|---|---|
| Yes . | No . | No . | Low (2-13/slide; <10 000) . | High >100 >10 000 . | ||||
| B0702 | 25 | 19 (75%) | 6 | 6 | 10 | 9 | 3 (15%) | 2 (8%) |
| A 0201 DOM | 28 | 21 (75%) | 7 | 7 | 16 | 5 | 2 (9%) | 1 (3.5%) |
| A 1101 DOM | 1 | 1 (100%) | 0 | 0 | 1 | 0 | 0 (0%) | 0 (0%) |
| A 0101 DOM | 4 | 4 (100%) | 0 | 0 | 2 | 2 | 0 (0%) | 0 (0%) |
| A 2402 DOM | 4 | 4 (100%) | 0 | 0 | 2 | 2 | 0 (0%) | 0 (0%) |
| A 2601 DOM | 4 | 2 (50%) | 2 | 2 | 1 | 1 | 1 (25%) | 1 (25%) |
| B 0801 DOM | 3 | 3 (100%) | 0 | 0 | 1 | 2 | 0 (0%) | 0 (0%) |
| B 40, 42, 44 DOM HERN Specific | 9 | 6 (66%) | 3 | 3 | 2 | 4 | 2 (24%) | 1 (11%) |
| B 35 DOM | 8 | 7 (87.5%) | 1 | 1 | 3 | 4 | 3 (37.5%) | 3 (37.5%) *P = .048 |
| Other HLA A,B,C alleles DOM | 13 | 11 (84%) | 2 | 2 | 4 | 7 | 2 (15%) | 0 (0%) |
| HLA DR alleles DOM | 14 | 13 (92%) | 1 | 1 | 4 | 9 | 7 (50%) | 5 (35%) |