Table 2. IFNA16 SNV ORs substratified... | American Society of Hematology

Table 2.

IFNA16 SNV ORs substratified according to JAK2^V617F

Gene	SNV	Alleles			P	OR*	95% CI
Cohort 1 (n = 52)
IFNA16	rs28368163	G/G†	GC	CC
Aggregate		38 (74.5%)	12 (23.5%)	1 (2.0%)	2.23 × 10^–5	5.40	2.32-12.53
JAK2^V617F+		24 (47.0%)	5 (9.8%)	1 (2.0%)	.49‡	0.26‡	0.00-14.69
JAK2^V617F–		11 (21.6%)	6 (11.8%)	0 (0%)	2.01 × 10⁻⁵	8.60	2.75-26.94
IFNA16	rs28368160	G/G	GC	CC
Aggregate (N = 46)		37 (80.4%)	9 (17.7%)	0 (0%)	.0004	4.71	1.87-11.81
JAK2^V617F+		25 (54.4%)	4 (7.8%)	0 (0%)	.36‡	0.18‡	0.00-10.09‡
JAK2^V617F–		12 (26.1%)	5 (9.8%)	0 (0%)	.0001	7.84	2.35-26.21
Cohort 2 (n = 54)
IFNA16	rs28368163	G/G	GC	CC
Aggregate		42 (77.8%)	12 (22.2%)	0 (0%)	.0002	4.51	1.92-10.56
JAK2^V617F+		25 (46.3%)	9 (16.7%)	0 (0%)	.62‡	0.37‡	0.00-20.1‡
JAK2^V617F–		17 (31.5%)	3 (5.6%)	0 (0%)	.12	2.78	0.72-10.73
Cohort 1+cohort 2 (n = 105)
IFNA16	rs28368163	G/G	GC	CC
Aggregate		80 (76.2%)	24 (22.9%)	1 (0.96%)	3.23 × 10^–6	4.92	2.40-10.10
JAK2^V617F+		49 (46.7%)	14 (13.3%)	1 (0.96%)	.31‡	0.55‡	0.00-16.45‡
JAK2^V617F–		28 (26.7%)	9 (8.6%)	0 (0%)	.0002	5.01	1.98-12.94

Gene	SNV	Alleles			P	OR*	95% CI
Cohort 1 (n = 52)
IFNA16	rs28368163	G/G†	GC	CC
Aggregate		38 (74.5%)	12 (23.5%)	1 (2.0%)	2.23 × 10^–5	5.40	2.32-12.53
JAK2^V617F+		24 (47.0%)	5 (9.8%)	1 (2.0%)	.49‡	0.26‡	0.00-14.69
JAK2^V617F–		11 (21.6%)	6 (11.8%)	0 (0%)	2.01 × 10⁻⁵	8.60	2.75-26.94
IFNA16	rs28368160	G/G	GC	CC
Aggregate (N = 46)		37 (80.4%)	9 (17.7%)	0 (0%)	.0004	4.71	1.87-11.81
JAK2^V617F+		25 (54.4%)	4 (7.8%)	0 (0%)	.36‡	0.18‡	0.00-10.09‡
JAK2^V617F–		12 (26.1%)	5 (9.8%)	0 (0%)	.0001	7.84	2.35-26.21
Cohort 2 (n = 54)
IFNA16	rs28368163	G/G	GC	CC
Aggregate		42 (77.8%)	12 (22.2%)	0 (0%)	.0002	4.51	1.92-10.56
JAK2^V617F+		25 (46.3%)	9 (16.7%)	0 (0%)	.62‡	0.37‡	0.00-20.1‡
JAK2^V617F–		17 (31.5%)	3 (5.6%)	0 (0%)	.12	2.78	0.72-10.73
Cohort 1+cohort 2 (n = 105)
IFNA16	rs28368163	G/G	GC	CC
Aggregate		80 (76.2%)	24 (22.9%)	1 (0.96%)	3.23 × 10^–6	4.92	2.40-10.10
JAK2^V617F+		49 (46.7%)	14 (13.3%)	1 (0.96%)	.31‡	0.55‡	0.00-16.45‡
JAK2^V617F–		28 (26.7%)	9 (8.6%)	0 (0%)	.0002	5.01	1.98-12.94

The χ² test using genotyped controls (N = 218).

C, minor (variant) allele; G, major allele.

Haldane-Anscombe correction.