Patient characteristics, stratified for D-dimer level
| Variable (at index*) . | All . | D-dimer level . | |
|---|---|---|---|
| High† . | Low to moderate† . | ||
| No. of patients (% of all) | 61 (100) | 17 (28) | 44 (72) |
| Age, median (range), y | 36 (18-84) | 39 (19-84) | 36 (18-80) |
| Female | 32 (52) | 9 (53) | 23 (52) |
| BMI ≥ 25 kg/m2 | 43 (70) | 11 (65) | 32 (73) |
| ALL subgroup | |||
| B-cell ALL | 52 (85) | 13 (76) | 39 (89) |
| T-cell ALL | 5 (8) | 3 (18) | 2 (5) |
| Mixed phenotype ALL | 4 (7) | 1 (6) | 3 (7) |
| Ph+ALL | 12 (20) | 3 (18) | 9 (20) |
| Ph-like ALL | 5 (8) | 2 (12) | 3 (13) |
| Asparaginase-based treatment‡ | 41 (67) | 12 (71) | 29 (66) |
| Previous venous thrombosis | 1 (2) | 0 (0) | 1 (2) |
| Previous arterial thrombosis | 2 (3) | 0 (0) | 2 (5) |
| D-dimer, median (range), µg/mL§ | 2.1 (0.26-20) | 9.1 (5.5-20) | 1.2 (0.26-3.98) |
| Platelet count, median (range) (×109/L)§ | 71 (7-445) | 50 (9-445) | 87 (7-286) |
| Fibrinogen, median (range), mg/dL§ | 417 (126-974) | 457 (126-974) | 410 (249-840) |
| PT, median (range), s§ | 14 (10-25) | 16 (13-19) | 14 (10-25) |
| DIC score, median (range)ǁ | 4 (0-7) | 5 (3-7) | 4 (0-5) |
| Variable (at index*) . | All . | D-dimer level . | |
|---|---|---|---|
| High† . | Low to moderate† . | ||
| No. of patients (% of all) | 61 (100) | 17 (28) | 44 (72) |
| Age, median (range), y | 36 (18-84) | 39 (19-84) | 36 (18-80) |
| Female | 32 (52) | 9 (53) | 23 (52) |
| BMI ≥ 25 kg/m2 | 43 (70) | 11 (65) | 32 (73) |
| ALL subgroup | |||
| B-cell ALL | 52 (85) | 13 (76) | 39 (89) |
| T-cell ALL | 5 (8) | 3 (18) | 2 (5) |
| Mixed phenotype ALL | 4 (7) | 1 (6) | 3 (7) |
| Ph+ALL | 12 (20) | 3 (18) | 9 (20) |
| Ph-like ALL | 5 (8) | 2 (12) | 3 (13) |
| Asparaginase-based treatment‡ | 41 (67) | 12 (71) | 29 (66) |
| Previous venous thrombosis | 1 (2) | 0 (0) | 1 (2) |
| Previous arterial thrombosis | 2 (3) | 0 (0) | 2 (5) |
| D-dimer, median (range), µg/mL§ | 2.1 (0.26-20) | 9.1 (5.5-20) | 1.2 (0.26-3.98) |
| Platelet count, median (range) (×109/L)§ | 71 (7-445) | 50 (9-445) | 87 (7-286) |
| Fibrinogen, median (range), mg/dL§ | 417 (126-974) | 457 (126-974) | 410 (249-840) |
| PT, median (range), s§ | 14 (10-25) | 16 (13-19) | 14 (10-25) |
| DIC score, median (range)ǁ | 4 (0-7) | 5 (3-7) | 4 (0-5) |
Data are expressed as n (%) unless otherwise indicated.
Ph, Philadelphia chromosome; PT, prothrombin time.
Study index defined as date of ALL diagnosis.
D-dimer level at index: high, ≥4 µg/mL FEU; low to moderate, <4 µg/mL FEU.
Defined as at least 1 dose of asparaginase during 100 days after study index, before censorship.
Reference range for laboratory variables: D-dimer, <0.40 µg/mL FEU; platelet count, 150 to 450 × 109/L; fibrinogen, 180 to 409 mg/dL; and PT, 11.8 to 14.4 seconds.
Calculated using the ISTH scoring system from Taylor et al.16