Thrombosis, hemorrhage, and phenotypic evolution: history and risk during the follow-up in the population
| . | . | Cohort . | ET . | PV . | Other MPNs . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameters . | . | Nb or median . | % or range . | Nb or median . | % or range . | Nb or median . | % or range . | Nb or median . | % or range . | P . |
| History of thromboses | 49 | 11.1 | 27 | 8.5 | 17 | 21.5 | 5 | 11.4 | .007 | |
| New thromboses | 49 | 11.1 | 32 | 10.1 | 13 | 16.3 | 4 | 9.1 | .27 | |
| Median time | 5 | 0.1-28.5 | 4.6 | 0.2-28.5 | 4.5 | 0.1-19.4 | 9.6 | 4.1-18.2 | ||
| Incidence (%) | At 1 y | 6 | 1.36 | 4 | 1.26 | 2 | 2.5 | 0 | — | |
| At 5 y | 25 | 5.67 | 17 | 5.36 | 7 | 8.75 | 1 | 2.27 | ||
| At 10 y | 35 | 7.94 | 25 | 7.89 | 8 | 10 | 2 | 4.55 | ||
| Incidence (% pt/y) | 1.16 | 1.14 | 1.31 | 0.94 | ||||||
| Recurrence | 17 | 34.7 | 11 | 34.4 | 4 | 30.8 | 2 | 50 | .8 | |
| History of hemorrhages | 25 | 5.7 | 19 | 6 | 4 | 5.1 | 2 | 4.5 | 1 | |
| New hemorrhages | 44 | 9.9 | 27 | 8.5 | 11 | 13.8 | 6 | 13.6 | .23 | |
| Median time | 4.65 | 0.06-35.1 | 3.25 | 0.06-20.98 | 12.5 | 1.64-35.1 | 8.4 | 1-19.21 | ||
| Incidence (%) | At 1 y | 7 | 1.6 | 6 | 1.93 | 0 | — | 1 | 2.27 | .44 |
| At 5 y | 19 | 4.37 | 14 | 4.5 | 3 | 3.8 | 3 | 6.8 | .7 | |
| At 10 y | 24 | 5.52 | 18 | 5.79 | 3 | 3.8 | 3 | 6.8 | .78 | |
| Incidence (% pt/y) | 1.04 | 0.94 | 1.17 | 1.4 | ||||||
| Evolutions | Total | 48 | 10.9 | 33 | 10.4 | 8 | 10 | 7 | 15.6 | .5 |
| PV | 12 | 2.7 | 9 | 2.8 | — | — | 3 | 6.7 | .17 | |
| MF | 33 | 7.5 | 23 | 7.3 | 7 | 8.8 | 3 | 6.7 | .91 | |
| AP/AML | 3 | 0.7 | 1 | 0.3 | 1 | 1.2 | 1 | 2.2 | .19 | |
| Incidence PV (%) | At 1 y | 0 | — | 0 | — | NA | NA | 0 | — | |
| At 5 y | 3 | 0.68 | 1 | 0.31 | NA | NA | 2 | 4.44 | .04 | |
| At 10 y | 6 | 1.36 | 4 | 1.26 | NA | NA | 2 | 4.44 | .16 | |
| Incidence MF (%) | At 1 y | 0 | — | 0 | — | 0 | — | 0 | — | |
| At 5 y | 11 | 2.49 | 6 | 1.89 | 3 | 3.75 | 2 | 4.44 | .29 | |
| At 10 y | 18 | 4.07 | 12 | 3.79 | 4 | 5 | 2 | 4.44 | .73 | |
| Incidence (% pt/y) | Total | 1.13 | 1.14 | 0.84 | 1.63 | |||||
| PV | 0.28 | 0.31 | 0 | 0.69 | ||||||
| MF | 0.77 | 0.8 | 0.73 | 0.69 | ||||||
| AP/AML | 0.07 | 0.03 | 0.03 | 0.23 | ||||||
| . | . | Cohort . | ET . | PV . | Other MPNs . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameters . | . | Nb or median . | % or range . | Nb or median . | % or range . | Nb or median . | % or range . | Nb or median . | % or range . | P . |
| History of thromboses | 49 | 11.1 | 27 | 8.5 | 17 | 21.5 | 5 | 11.4 | .007 | |
| New thromboses | 49 | 11.1 | 32 | 10.1 | 13 | 16.3 | 4 | 9.1 | .27 | |
| Median time | 5 | 0.1-28.5 | 4.6 | 0.2-28.5 | 4.5 | 0.1-19.4 | 9.6 | 4.1-18.2 | ||
| Incidence (%) | At 1 y | 6 | 1.36 | 4 | 1.26 | 2 | 2.5 | 0 | — | |
| At 5 y | 25 | 5.67 | 17 | 5.36 | 7 | 8.75 | 1 | 2.27 | ||
| At 10 y | 35 | 7.94 | 25 | 7.89 | 8 | 10 | 2 | 4.55 | ||
| Incidence (% pt/y) | 1.16 | 1.14 | 1.31 | 0.94 | ||||||
| Recurrence | 17 | 34.7 | 11 | 34.4 | 4 | 30.8 | 2 | 50 | .8 | |
| History of hemorrhages | 25 | 5.7 | 19 | 6 | 4 | 5.1 | 2 | 4.5 | 1 | |
| New hemorrhages | 44 | 9.9 | 27 | 8.5 | 11 | 13.8 | 6 | 13.6 | .23 | |
| Median time | 4.65 | 0.06-35.1 | 3.25 | 0.06-20.98 | 12.5 | 1.64-35.1 | 8.4 | 1-19.21 | ||
| Incidence (%) | At 1 y | 7 | 1.6 | 6 | 1.93 | 0 | — | 1 | 2.27 | .44 |
| At 5 y | 19 | 4.37 | 14 | 4.5 | 3 | 3.8 | 3 | 6.8 | .7 | |
| At 10 y | 24 | 5.52 | 18 | 5.79 | 3 | 3.8 | 3 | 6.8 | .78 | |
| Incidence (% pt/y) | 1.04 | 0.94 | 1.17 | 1.4 | ||||||
| Evolutions | Total | 48 | 10.9 | 33 | 10.4 | 8 | 10 | 7 | 15.6 | .5 |
| PV | 12 | 2.7 | 9 | 2.8 | — | — | 3 | 6.7 | .17 | |
| MF | 33 | 7.5 | 23 | 7.3 | 7 | 8.8 | 3 | 6.7 | .91 | |
| AP/AML | 3 | 0.7 | 1 | 0.3 | 1 | 1.2 | 1 | 2.2 | .19 | |
| Incidence PV (%) | At 1 y | 0 | — | 0 | — | NA | NA | 0 | — | |
| At 5 y | 3 | 0.68 | 1 | 0.31 | NA | NA | 2 | 4.44 | .04 | |
| At 10 y | 6 | 1.36 | 4 | 1.26 | NA | NA | 2 | 4.44 | .16 | |
| Incidence MF (%) | At 1 y | 0 | — | 0 | — | 0 | — | 0 | — | |
| At 5 y | 11 | 2.49 | 6 | 1.89 | 3 | 3.75 | 2 | 4.44 | .29 | |
| At 10 y | 18 | 4.07 | 12 | 3.79 | 4 | 5 | 2 | 4.44 | .73 | |
| Incidence (% pt/y) | Total | 1.13 | 1.14 | 0.84 | 1.63 | |||||
| PV | 0.28 | 0.31 | 0 | 0.69 | ||||||
| MF | 0.77 | 0.8 | 0.73 | 0.69 | ||||||
| AP/AML | 0.07 | 0.03 | 0.03 | 0.23 | ||||||
Nb, number; NA, not applicable.