Table 2. Changes in hemostatic... | American Society of Hematology

Table 2.

Changes in hemostatic parameters over the course of the study

	Study arm	Baseline; median (IQR)	T1; median (IQR)	Fold change (vs baseline)	T3; median (IQR)	Fold change (vs baseline)	T4; median (IQR)	Fold change (vs baseline)
FVIII:C (%)	Arm A	23.8 (7-50.7)	48.3 (16.7-66.4)	2	75.9 (23.2-101.7)	3.2	66.7 (17.5-124.9)	2.8
	Arm B	21.4 (6.9-50.4)	37.2 (21.6-111.3)	1.7	47.4 (20.4-111.2)	2.2	42.8 (19.6-207.5)	2
	Arm C	32 (7.3-65.1)	47.7 (15.6-155.2)	1.5	63.3 (22.6-168.6)	2	77 (30.1-166.1)	2.4
	Arm D	14.6 (8.2-70.6)	29.6 (10.9-151.9)	2	23.9 (9.3-133)	1.4	20.3 (9.1-101.8)	1.4
VWG:Ag (%)	Arm A	84.9 (80.4-121.3)	118.8 (107.3-176)	1.4	173.9 (145.2-266.8)	2*†	200.8 (128.2-266.8)	2.4*†
	Arm B	131.5 (89-172)	156.6 (117.3-197.7)	1.2	181.6 (139.6-227.1)	1.4*†	265.6 (145.2-288.9)	2*†
	Arm C	88.7 (64.7-123.9)	101.4 (71.1-112.5)	1.1	107.5 (89.1-119.5)	1.2	97.3 (93.8-165.5)	1.1
	Arm D	78.8 (61.2-89)	80.3 (65.6-134.7)	1	72.8 (56.4-130)	1	76.8 (57.4-125.3)	1
VWF:Gp1bM (%)	Arm A	88.7 (68.2-126.9)	145.7 (114.9-169.3)	1.6	207.4 (169.7-286.8)	2.3*	221.8 (233.8-152.1)	2.5*
	Arm B	139.7 (77.3-157.7)	179.3 (145.9-210.6)	1.3	192.8 (99-251.2)	1.4*	185.7 (136.4-228.6)	1.3*
	Arm C	77.9 (56.3-127.2)	113.5 (82.8-141.8)	1.5	141.3 (91.7-156.1)	1.8	146.9 (119.1-214.7)	1.9*
	Arm D	75.9 (58.3-94.9)	76.2 (67.4-138.7)	1	73.6 (63.4-137)	1	72.3 (63.9-124.1)	1
Platelet count (x10³/L)	Arm A	233.5 (212-275)	236.5 (203.5-289)	1	297 (234-326.5)	1.3	226.5 (195-260.8)	1
	Arm B	282 (175.3-298.3)	263 (171-302.8)	0.9	265.5 (165.8-293)	0.9	256.5 (167.3-296.3)	0.9
	Arm C	235 (200-253)	246 (219-275)	1	216 (199-267)	0.9	222 (200-241)	0.9
	Arm D	260 (255.5-292.5)	281 (245.5-332)	1.1	235 (216-274.5)	0.9	264 (223.5-286)	1
Col/Epi closure time (s)	Arm A	143.5 (122.3-153.5)	82 (75-89)	0.6	77.5 (70.8-83.8)	0.5*	99.5 (75.3-110)	0.7*
	Arm B	139 (111.3-148.3)	78.5 (74.3-111.3)	0.6	91 (71.5-100.5)	0.7*	94.5 (77.5-117.3)	0.7*
	Arm C	129.5 (97.8-149.8)	121 (106-173)	0.9	102 (76-119)	0.8*	96 (82-112)	0.7*
	Arm D	142 (128.5-177.5)	143 (113-162.5)	1	150 (113-177.5)	1	166 (110-183)	1.1
Col/ADP closure time (s)	Arm A	100.5 (74.3-119.5)	77 (60-81)	0.8	58 (53-76.3)	0.6*	76.5 (65.5-87.3)	0.8*
	Arm B	80.5 (61.5-100.8)	64.5 (48.8-81)	0.8	63 (59.3-66)	0.8*	62 (56-69.8)	0.8*
	Arm C	104 (85-115.5)	83 (62-97)	0.8	75 (65-78)	0.7*	67 (64-79)	0.6*
	Arm D	105 (90-120.5)	103 (79.5-108.5)	1	91 (85-113.5)	0.9	103 (91.5-130)	1
Hematocrit (%)	Arm A	41.7 (40.6-44.6)	41 (37.8-42.3)	1	41.6 (40.3-44.9)	1	40.2 (36.7-40.6)	1
	Arm B	43.6 (42.3-45.6)	41.4 (40-41.4)	0.9	40.5 (39.6-43.1)	0.9	40.4 (39.4-42.7)	0.9
	Arm C	44.2 (39.8-45.4)	44.9 (41.45.9)	1	40.9 (37.7-42.6)	0.9	41.4 (36.8-42.7)	0.9
	Arm D	43.3 (41.3-47.7)	44.5 (42.6-46.6)	1	40.4 (39.2-43.2)	0.9	40.6 (39.3-44.5)	0.9

	Study arm	Baseline; median (IQR)	T1; median (IQR)	Fold change (vs baseline)	T3; median (IQR)	Fold change (vs baseline)	T4; median (IQR)	Fold change (vs baseline)
FVIII:C (%)	Arm A	23.8 (7-50.7)	48.3 (16.7-66.4)	2	75.9 (23.2-101.7)	3.2	66.7 (17.5-124.9)	2.8
	Arm B	21.4 (6.9-50.4)	37.2 (21.6-111.3)	1.7	47.4 (20.4-111.2)	2.2	42.8 (19.6-207.5)	2
	Arm C	32 (7.3-65.1)	47.7 (15.6-155.2)	1.5	63.3 (22.6-168.6)	2	77 (30.1-166.1)	2.4
	Arm D	14.6 (8.2-70.6)	29.6 (10.9-151.9)	2	23.9 (9.3-133)	1.4	20.3 (9.1-101.8)	1.4
VWG:Ag (%)	Arm A	84.9 (80.4-121.3)	118.8 (107.3-176)	1.4	173.9 (145.2-266.8)	2*†	200.8 (128.2-266.8)	2.4*†
	Arm B	131.5 (89-172)	156.6 (117.3-197.7)	1.2	181.6 (139.6-227.1)	1.4*†	265.6 (145.2-288.9)	2*†
	Arm C	88.7 (64.7-123.9)	101.4 (71.1-112.5)	1.1	107.5 (89.1-119.5)	1.2	97.3 (93.8-165.5)	1.1
	Arm D	78.8 (61.2-89)	80.3 (65.6-134.7)	1	72.8 (56.4-130)	1	76.8 (57.4-125.3)	1
VWF:Gp1bM (%)	Arm A	88.7 (68.2-126.9)	145.7 (114.9-169.3)	1.6	207.4 (169.7-286.8)	2.3*	221.8 (233.8-152.1)	2.5*
	Arm B	139.7 (77.3-157.7)	179.3 (145.9-210.6)	1.3	192.8 (99-251.2)	1.4*	185.7 (136.4-228.6)	1.3*
	Arm C	77.9 (56.3-127.2)	113.5 (82.8-141.8)	1.5	141.3 (91.7-156.1)	1.8	146.9 (119.1-214.7)	1.9*
	Arm D	75.9 (58.3-94.9)	76.2 (67.4-138.7)	1	73.6 (63.4-137)	1	72.3 (63.9-124.1)	1
Platelet count (x10³/L)	Arm A	233.5 (212-275)	236.5 (203.5-289)	1	297 (234-326.5)	1.3	226.5 (195-260.8)	1
	Arm B	282 (175.3-298.3)	263 (171-302.8)	0.9	265.5 (165.8-293)	0.9	256.5 (167.3-296.3)	0.9
	Arm C	235 (200-253)	246 (219-275)	1	216 (199-267)	0.9	222 (200-241)	0.9
	Arm D	260 (255.5-292.5)	281 (245.5-332)	1.1	235 (216-274.5)	0.9	264 (223.5-286)	1
Col/Epi closure time (s)	Arm A	143.5 (122.3-153.5)	82 (75-89)	0.6	77.5 (70.8-83.8)	0.5*	99.5 (75.3-110)	0.7*
	Arm B	139 (111.3-148.3)	78.5 (74.3-111.3)	0.6	91 (71.5-100.5)	0.7*	94.5 (77.5-117.3)	0.7*
	Arm C	129.5 (97.8-149.8)	121 (106-173)	0.9	102 (76-119)	0.8*	96 (82-112)	0.7*
	Arm D	142 (128.5-177.5)	143 (113-162.5)	1	150 (113-177.5)	1	166 (110-183)	1.1
Col/ADP closure time (s)	Arm A	100.5 (74.3-119.5)	77 (60-81)	0.8	58 (53-76.3)	0.6*	76.5 (65.5-87.3)	0.8*
	Arm B	80.5 (61.5-100.8)	64.5 (48.8-81)	0.8	63 (59.3-66)	0.8*	62 (56-69.8)	0.8*
	Arm C	104 (85-115.5)	83 (62-97)	0.8	75 (65-78)	0.7*	67 (64-79)	0.6*
	Arm D	105 (90-120.5)	103 (79.5-108.5)	1	91 (85-113.5)	0.9	103 (91.5-130)	1
Hematocrit (%)	Arm A	41.7 (40.6-44.6)	41 (37.8-42.3)	1	41.6 (40.3-44.9)	1	40.2 (36.7-40.6)	1
	Arm B	43.6 (42.3-45.6)	41.4 (40-41.4)	0.9	40.5 (39.6-43.1)	0.9	40.4 (39.4-42.7)	0.9
	Arm C	44.2 (39.8-45.4)	44.9 (41.45.9)	1	40.9 (37.7-42.6)	0.9	41.4 (36.8-42.7)	0.9
	Arm D	43.3 (41.3-47.7)	44.5 (42.6-46.6)	1	40.4 (39.2-43.2)	0.9	40.6 (39.3-44.5)	0.9

P < 0.05 (compared with arm D).

†

P < 0.05 (compared with arm C).

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