Table 3.

Most discriminative miRNAs for patients with and without cGVHD based on false discovery rates and predictive values

miRNANFDRNPVPPVNPV-CVPPV-CV
miR-122-5p 79 0.0264 0.700 0.746 0.588 0.758 
miR-148-3p 79 0.0264 0.548 0.838 0.554 0.824 
miR-365-3p 76 0.0264 0.645 0.812 0.643 0.763 
miR-378a-3p 79 0.0359 0.613 0.792 0.707 0.789 
miR-192-5p 79 0.0396 0.490 0.857 0.612 0.830 
miRNANFDRNPVPPVNPV-CVPPV-CV
miR-122-5p 79 0.0264 0.700 0.746 0.588 0.758 
miR-148-3p 79 0.0264 0.548 0.838 0.554 0.824 
miR-365-3p 76 0.0264 0.645 0.812 0.643 0.763 
miR-378a-3p 79 0.0359 0.613 0.792 0.707 0.789 
miR-192-5p 79 0.0396 0.490 0.857 0.612 0.830 

The table demonstrates the 5 most discriminative miRNAs as separated by patients with cGVHD and patients without cGVHD at 1-year control after allo-HSCT based on FDR. “N” denotes the number of patients with detectable serum levels of each miRNA. Predictive values were calculated by cutoff values set by use of Youden’s index.

NPV-CV, NPVs with crossvalidation; PPV-CV, positive predictive value with crossvalidation.

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