Drugs, supplements, and comorbidities affecting platelet functiona
| Drugs affecting platelet function6 . | |
|---|---|
| Class . | Examples . |
| Aspirin and other nonsteroidal inflammatory drugs | Ibuprofen, naproxen, indomethacin, diclofenac, meclofenamic acid, sulindac, Pepto Bismol |
| Glycoprotein IIb/IIIa inhibitors | Abciximab, eptifibatide, tirofiban |
| Phosphodiesterase inhibitors | Sildenafil |
| β-lactam antibiotics | Penicillins, cephalosporins |
| P2Y12 antagonists | Ticlopidine, clopidogrel, prasugrel, ticagrelor |
| Selective serotonin reuptake inhibitors | Fluoxetine, paroxetine, sertraline |
| Tricyclic antidepressants | Amitriptyline, doxepin, nortriptyline |
| Dietary supplements and foods7,8 | |
| Dietary supplements such as fish oils containing omega-3 fatty acids, vitamin E, vitamin B3 | |
| Herbal supplements such as ginkgo biloba, ginseng, turmeric, cinnamon, tarragon, willow, feverfew, dong quai, meadowsweet, pycnogenol (pine bark extract), guarana | |
| Ethanol and nonalcoholic beer | |
| Foods (likely only when consumed in large quantities or as a supplement) such as cumin, cloves, onion, garlic, black tree fungus, ginger, aspartame, red/purple grapes (including grape juice, raisins, red wine, grape seeds), green tea, kiwi fruit, tomatoes, blueberries | |
| Medical conditions affecting platelet function7 | |
| Hematologic disorders such as myeloproliferative neoplasm, myelodysplastic syndrome, paraproteinemia, Gaucher disease | |
| Renal failure | |
| Liver disease | |
| Abnormal cardiac anatomy such as valvular heart disease, left ventricular assistive device, cardiopulmonary bypass | |
| Connective tissue diseases such as Ehlers-Danlos | |
| Drugs affecting platelet function6 . | |
|---|---|
| Class . | Examples . |
| Aspirin and other nonsteroidal inflammatory drugs | Ibuprofen, naproxen, indomethacin, diclofenac, meclofenamic acid, sulindac, Pepto Bismol |
| Glycoprotein IIb/IIIa inhibitors | Abciximab, eptifibatide, tirofiban |
| Phosphodiesterase inhibitors | Sildenafil |
| β-lactam antibiotics | Penicillins, cephalosporins |
| P2Y12 antagonists | Ticlopidine, clopidogrel, prasugrel, ticagrelor |
| Selective serotonin reuptake inhibitors | Fluoxetine, paroxetine, sertraline |
| Tricyclic antidepressants | Amitriptyline, doxepin, nortriptyline |
| Dietary supplements and foods7,8 | |
| Dietary supplements such as fish oils containing omega-3 fatty acids, vitamin E, vitamin B3 | |
| Herbal supplements such as ginkgo biloba, ginseng, turmeric, cinnamon, tarragon, willow, feverfew, dong quai, meadowsweet, pycnogenol (pine bark extract), guarana | |
| Ethanol and nonalcoholic beer | |
| Foods (likely only when consumed in large quantities or as a supplement) such as cumin, cloves, onion, garlic, black tree fungus, ginger, aspartame, red/purple grapes (including grape juice, raisins, red wine, grape seeds), green tea, kiwi fruit, tomatoes, blueberries | |
| Medical conditions affecting platelet function7 | |
| Hematologic disorders such as myeloproliferative neoplasm, myelodysplastic syndrome, paraproteinemia, Gaucher disease | |
| Renal failure | |
| Liver disease | |
| Abnormal cardiac anatomy such as valvular heart disease, left ventricular assistive device, cardiopulmonary bypass | |
| Connective tissue diseases such as Ehlers-Danlos | |
Please note this list is not all inclusive and does not include medications and supplements that can cause thrombocytopenia.