Table 1.

Drugs, supplements, and comorbidities affecting platelet functiona

Drugs affecting platelet function
ClassExamples
 Aspirin and other nonsteroidal inflammatory drugs Ibuprofen, naproxen, indomethacin, diclofenac, meclofenamic acid, sulindac, Pepto Bismol 
 Glycoprotein IIb/IIIa inhibitors Abciximab, eptifibatide, tirofiban 
 Phosphodiesterase inhibitors Sildenafil 
 β-lactam antibiotics Penicillins, cephalosporins 
 P2Y12 antagonists Ticlopidine, clopidogrel, prasugrel, ticagrelor 
 Selective serotonin reuptake inhibitors Fluoxetine, paroxetine, sertraline 
 Tricyclic antidepressants Amitriptyline, doxepin, nortriptyline 
Dietary supplements and foods7,8  
 Dietary supplements such as fish oils containing omega-3 fatty acids, vitamin E, vitamin B3 
 Herbal supplements such as ginkgo biloba, ginseng, turmeric, cinnamon, tarragon, willow, feverfew, dong quai, meadowsweet, pycnogenol (pine bark extract), guarana 
 Ethanol and nonalcoholic beer 
 Foods (likely only when consumed in large quantities or as a supplement) such as cumin, cloves, onion, garlic, black tree fungus, ginger, aspartame, red/purple grapes (including grape juice, raisins, red wine, grape seeds), green tea, kiwi fruit, tomatoes, blueberries 
Medical conditions affecting platelet function 
 Hematologic disorders such as myeloproliferative neoplasm, myelodysplastic syndrome, paraproteinemia, Gaucher disease 
 Renal failure 
 Liver disease 
 Abnormal cardiac anatomy such as valvular heart disease, left ventricular assistive device, cardiopulmonary bypass 
 Connective tissue diseases such as Ehlers-Danlos 
Drugs affecting platelet function
ClassExamples
 Aspirin and other nonsteroidal inflammatory drugs Ibuprofen, naproxen, indomethacin, diclofenac, meclofenamic acid, sulindac, Pepto Bismol 
 Glycoprotein IIb/IIIa inhibitors Abciximab, eptifibatide, tirofiban 
 Phosphodiesterase inhibitors Sildenafil 
 β-lactam antibiotics Penicillins, cephalosporins 
 P2Y12 antagonists Ticlopidine, clopidogrel, prasugrel, ticagrelor 
 Selective serotonin reuptake inhibitors Fluoxetine, paroxetine, sertraline 
 Tricyclic antidepressants Amitriptyline, doxepin, nortriptyline 
Dietary supplements and foods7,8  
 Dietary supplements such as fish oils containing omega-3 fatty acids, vitamin E, vitamin B3 
 Herbal supplements such as ginkgo biloba, ginseng, turmeric, cinnamon, tarragon, willow, feverfew, dong quai, meadowsweet, pycnogenol (pine bark extract), guarana 
 Ethanol and nonalcoholic beer 
 Foods (likely only when consumed in large quantities or as a supplement) such as cumin, cloves, onion, garlic, black tree fungus, ginger, aspartame, red/purple grapes (including grape juice, raisins, red wine, grape seeds), green tea, kiwi fruit, tomatoes, blueberries 
Medical conditions affecting platelet function 
 Hematologic disorders such as myeloproliferative neoplasm, myelodysplastic syndrome, paraproteinemia, Gaucher disease 
 Renal failure 
 Liver disease 
 Abnormal cardiac anatomy such as valvular heart disease, left ventricular assistive device, cardiopulmonary bypass 
 Connective tissue diseases such as Ehlers-Danlos 
a

Please note this list is not all inclusive and does not include medications and supplements that can cause thrombocytopenia.

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