Table 1. Comparison of considerations... | American Society of Hematology

Table 1.

Comparison of considerations for intensification strategies for relapsed follicular lymphoma—CAR-T vs autologous transplant

	Autologous transplant	CAR-T
Requires chemosensitive disease	Yes	No
Potential benefit limited to early in relapsed course	Yes	No^*
Short-term toxicities	Mucositis, infection, sepsis, pneumonitis, poor engraftment	CRS, ICANS, cytopenia, infection
Long-term toxicities	Therapy-related myeloid malignancies	B-cell aplasia, hypogammaglobulinemia, cytopenia^*
Other considerations	Need for adequate marrow reserve for stem cell collection, eligibility limited to fit patients	Need for adequate lymphocyte count, wait time for and requirement of successful T-cell manufacturing, likely lower fitness requirement than autologous transplant

	Autologous transplant	CAR-T
Requires chemosensitive disease	Yes	No
Potential benefit limited to early in relapsed course	Yes	No^*
Short-term toxicities	Mucositis, infection, sepsis, pneumonitis, poor engraftment	CRS, ICANS, cytopenia, infection
Long-term toxicities	Therapy-related myeloid malignancies	B-cell aplasia, hypogammaglobulinemia, cytopenia^*
Other considerations	Need for adequate marrow reserve for stem cell collection, eligibility limited to fit patients	Need for adequate lymphocyte count, wait time for and requirement of successful T-cell manufacturing, likely lower fitness requirement than autologous transplant

Long-term follow-up evaluating both risk and benefit in large cohorts of patients with FL receiving CAR-T is limited.

ICANS, immune effector cell-associated neurotoxicity syndrome.