Summary of patients diagnosed with CML during pregnancy at Hammersmith Hospital, London
| Characteristics (N = 11) . | Median (range); N [%] . |
|---|---|
| Age at diagnosis (years) | 33 (25-40) |
| Trimester | |
| 1 | 6 [55] |
| 2 | 5 [45] |
| CML phase | |
| Chronic | 11 [100] |
| WBC ( × 109/L) | 80 (14.7-215.4) |
| Sokal score | |
| Low | 6 [55] |
| Intermediate | 2 [18] |
| No data | 3 [27] |
| Pregnancy outcome | |
| Live birth | 10 [91] |
| Miscarriage | 1 [9] |
| Management in pregnancy | |
| Observation | 3 [27] |
| IFNa | 2 [18] |
| Leukapheresis | 3 [27] |
| IFN + leukapheresis | 3 [27] |
| TKI started after pregnancy end | |
| Imatinib | 8 (73) |
| Dasatinib | 3 (27) |
| Duration of TKI delay (months) | 7 (1-10) |
| ≥MR1 at 3 mo | 11 [100] |
| ≥CCyR at 6 mo | 9 [82] |
| ≥MMR at 12 mo | 8 [73] |
| Characteristics (N = 11) . | Median (range); N [%] . |
|---|---|
| Age at diagnosis (years) | 33 (25-40) |
| Trimester | |
| 1 | 6 [55] |
| 2 | 5 [45] |
| CML phase | |
| Chronic | 11 [100] |
| WBC ( × 109/L) | 80 (14.7-215.4) |
| Sokal score | |
| Low | 6 [55] |
| Intermediate | 2 [18] |
| No data | 3 [27] |
| Pregnancy outcome | |
| Live birth | 10 [91] |
| Miscarriage | 1 [9] |
| Management in pregnancy | |
| Observation | 3 [27] |
| IFNa | 2 [18] |
| Leukapheresis | 3 [27] |
| IFN + leukapheresis | 3 [27] |
| TKI started after pregnancy end | |
| Imatinib | 8 (73) |
| Dasatinib | 3 (27) |
| Duration of TKI delay (months) | 7 (1-10) |
| ≥MR1 at 3 mo | 11 [100] |
| ≥CCyR at 6 mo | 9 [82] |
| ≥MMR at 12 mo | 8 [73] |
One patient was switched from IFN-α to PEG-IFN-α due to an adverse reaction to the drug.